Most Read Articles
Jairia Dela Cruz, 22 Apr 2020
A wristwatch-like device that monitors pulse, breathing and blood oxygen levels of the user allows physicians to provide care remotely both in hospital and nontraditional settings, and may help in the fight against the coronavirus disease 2019 (COVID-19) pandemic.
Roshini Claire Anthony, 6 days ago

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Stephen Padilla, 5 days ago
Herd immunity will not work in the novel coronavirus disease (COVID-19), according to an infectious disease expert who addressed over 3,600 primary care physicians (PCP) from Asia Pacific at the inaugural webcast of the MIMS COVID Conversations Series.

Faecal microbiota transplantation beneficial for survival in patients with refractory SFCDI

17 Feb 2020

An inpatient faecal microbiota transplantation (FMT) programme yields substantial reductions in Clostridioides difficile infection (CDI)-related mortality in patients with refractory severe or fulminant (SF) CDI, a study has found.

Researchers examined the medical records of 430 patients (mean age, 61.1 years; 49.3 percent female) hospitalized for SFCDI at a single centre, among whom 205 were admitted prior to the implementation of the FMT programme (pre-FMT) and 225 were admitted after (post-FMT). They also performed subgroup analyses involving 199 patients with fulminant CDI and 110 patients with refractory SFCDI (no improvement after 5 days of maximal anti-CDI antibiotic therapy).

Fifty patients underwent FMT for refractory SFCDI, with a median of two FMTs per patient. Among the 16 refractory SFCDI patients in the post-FMT period who did not receive FMT, six underwent colectomy (five survived; one died within 30 days), three continued with medical therapy and survived, and the remaining seven died due to withdrawal of care or anatomic issues precluding FMT delivery (obstructing distal colon cancer not allowing passage of an endoscope).

Rates of CDI-related mortality were lower post-FMT (10.2 percent pre-FMT vs 4.4 percent; p=0.02). Subgroup analyses confirmed that CDI-related mortality was lower post-FMT in the subgroup of patients with fulminant CDI (21.3 percent vs 9.1 percent; p=0.015) and in the subgroup of those with refractory SFCDI. CDI-related mortality was 43.2 percent before the FMT programme vs 12.1 percent after (p<0.001).

Likewise, the FMT programme significantly reduced the rates of CDI-related colectomy in the overall population of patients with SFCDI (6.8 percent pre-FMT vs 2.7 percent post-FMT; p=0.041), in the subgroup of patients with fulminant CDI (15.7 percent vs 5.5 percent; p=0.017) and in the subgroup of those with refractory SFCDI (31.8 percent vs 7.6 percent; p=0.001).

The effect of FMT on CDI-related mortality remained significant for patients with refractory SFCDI on further analysis (p=0.023).

In light of the findings, the researchers said that FMT be considered in patients who fail maximal anti-CDI antimicrobial therapy who would otherwise be referred for surgical management.

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Most Read Articles
Jairia Dela Cruz, 22 Apr 2020
A wristwatch-like device that monitors pulse, breathing and blood oxygen levels of the user allows physicians to provide care remotely both in hospital and nontraditional settings, and may help in the fight against the coronavirus disease 2019 (COVID-19) pandemic.
Roshini Claire Anthony, 6 days ago

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Stephen Padilla, 5 days ago
Herd immunity will not work in the novel coronavirus disease (COVID-19), according to an infectious disease expert who addressed over 3,600 primary care physicians (PCP) from Asia Pacific at the inaugural webcast of the MIMS COVID Conversations Series.