Most Read Articles
Pearl Toh, 17 hours ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 2 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
6 days ago
Women with hyperemesis gravidarum during pregnancy are more likely to experience nausea and vomiting after caesarean section delivery, a recent study has found.

Faecal calprotectin levels tied to microscopic colitis risk

24 Dec 2019

High faecal calprotectin concentrations may be predictive of microscopic colitis in patients with chronic watery diarrhoea, a recent study has found.

Ninety-four patients underwent colonoscopy due to chronic water diarrhoea and were included in the analysis. Faecal samples were obtained 1–2 days before colonoscopy and subjected to enzyme-linked immunosorbent assays for the measurement of calprotectin levels. Thirty participants (mean age, 65.3±3.1 years; 80 percent female) had microscopic colitis; the remaining 64 (mean age, 52.2±1.9 years; 80 percent female) were designated as controls.

Researchers identified that the optimal cutoff for faecal calprotectin was >100 µg/g. At this threshold, the area under the curve was 0.73±0.06 (p<0.0001) for the prediction of microscopic colitis. The corresponding sensitivity and specificity values were 67 percent and 75 percent, respectively.

Similarly, this cutoff value yielded a positive and negative predictive values of 53 percent and 84 percent, respectively, for the diagnosis of microscopic colitis. When used as a triage tool, faecal calprotectin would have saved 10 of 30 microscopic colitis patients from undergoing colonoscopy.

Multivariate logistic regression analysis found that being diagnosed with microscopic colitis was significantly associated with having elevated faecal calprotectin levels (odds ratio [OR], 6, 95 percent confidence interval [CI], 2.2–16.3; p<0.001). The inverse was also true: elevated levels of faecal calprotectin significantly increased the risk of microscopic colitis (OR, 5.3, 95 percent CI, 2–14.1; p=0.001).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 17 hours ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 2 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
6 days ago
Women with hyperemesis gravidarum during pregnancy are more likely to experience nausea and vomiting after caesarean section delivery, a recent study has found.