Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
2 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 5 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.

Faecal calprotectin aids in measurement of rifaximin effect in IBS patients

07 Jan 2019
Crohn’s is not the end of the world, as Kathleen Baker’s silver medal proves

Faecal calprotectin (FC) may be a potential biomarker for measuring the effect of rifaximin in nonconstipated patients with irritable bowel syndrome (IBS), a recent study has found.

The study included 198 patients with gastrointestinal complaints and in whom FC levels were elevated. Participants were initially given 1,200 mg/day of rifaximin for 4 weeks, followed by FC tests. Treatment was maintained if FC measurements exceeded 11.5 mg/kg; rifaximin was discontinued after 12 weeks.

A total of 168 patients achieved normalized FC values. Most (71.0 percent; n=115) of them required 4 weeks of treatment, while 24.1 percent (n=39) and 4.9 percent (n=8) underwent 8 and 12 weeks of treatment, respectively. FC values did not normalize in 36 participants.

Abdominal symptoms improved in all treatment duration groups. For instance, in patients who required 4 weeks of treatment, mean Likert scale scores improved from 4.4±0.8 at baseline to 2.1±0.7 at treatment cessation (p<0.05). In the 8-week group, scores dropped from 4.5±0.7 at baseline to 2.2±0.8 (p<0.05).

Similarly, a significant improvement was observed in participants who achieved FC normalization after 12 weeks (4.7±1.0 to 1.9±0.9; p<0.5). FC values and Likert scores at baseline were not significantly different among groups.

In most cases, significant improvement in Likert scale scores occurred before the normalization of FC measurements, researchers pointed out.

In patients with persistently elevated mean FC values beyond the 12-week mark, measurable improvements in abdominal symptoms were also reported.

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Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
2 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 5 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.