Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Factors for Fabry disease progression during enzyme replacement therapy

16 Aug 2017

Hypertension, cardiac fibrosis, renal dysfunction and proteinuria predict faster progression of Fabry disease (FD) while on enzyme replacement therapy (ERT), according to a recent study.

Investigators classified 293 treatment-naïve FD patients (median age at initiation 45.5 years; 55.6 male) into two according to FD phenotype: classical (n=203) and nonclassical (n=90). All patients subsequently received ERT with either agalsidase alfa or agalsidase beta for 9 months.

Over a median follow-up of 6.8 (0.8 to 15.4) years, 102 (34.8 percent) clinical events in patients on ERT were recorded. The resulting rate of events was 0.66 per 10 patient years at risk. Cardiac events, observed in 53 patients, were the most common. This was followed by stroke or transient ischaemic attacks (n=24), renal events (n=16) and death (n=9).

Cox regression analysis showed that a history of clinical (hazard ratio [HR], 2.37; 95 percent CI, 1.47 to 3.85; p<0.001) and renal (HR, 1.29; 1.81 to 7.21; p<0.001) events prior to ERT initiation, and hypertension (HR, 1.87; 1.18 to 2.97; p<0.01) significantly raised the risk of new clinical events.

Additionally, the risk of clinical events significantly increased by 19 percent (p<0.001) with every 10 mL/min/1.73m2-decrease in estimated glomerular filtration rate (eGFR) at baseline. Patients with proteinuria also experienced a significant decline in eGFR (p=0.005).

An eGFR of <60 mL/min/1.73m2 was also significantly associated with a higher risk of development of clinical events during ERT (HR, 3.58; 2.12 to 6.05; p<0.001).

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.