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Factors associated with severe liver disease risk in type 2 diabetes

15 May 2019

Age, sex comorbidities and weight, among others, are associated with a heightened risk of developing severe liver disease among individuals with type 2 diabetes, according to a recent study.

The study used data from the National Diabetes Register in Sweden, including a total of 406,770 patients with type 2 diabetes and 2,033,850 matched general population controls who were followed for 21,596,934 person-years. 

Patients with type 2 diabetes were twice as likely as general population controls to develop severe liver disease, which is defined as a diagnosis of hepatocellular carcinoma, cirrhosis, decompensation, liver failure and/or death due to liver disease.

On Cox regression analysis, the hazard ratio for severe liver disease associated with type 2 diabetes was 2.28 (95 percent CI, 2.21–2.36).

Risk factors were higher age, male sex, higher body mass index, lower glomerular filtration rate, microalbuminuria, hypertension and smoking. On the other hand, statin use conferred a protective benefit against the risk of severe liver disease.

The present data provide important information that can help identify those at highest risk of developing severe liver disease, researchers said.

Type 2 diabetes is a known risk factor for liver abnormalities such as cirrhosis and hepatocellular carcinoma. On the other hand, an excessive accumulation of fat in the liver may worsen insulin resistance and lead to severe metabolic dysfunction. [Sultan Qaboos Univ Med J 2016;16:e132-e141]

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Most Read Articles
2 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

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Empagliflozin treatment in patients with type 2 diabetes mellitus exerts beneficial effects on cardiovascular (CV) risk factors, including blood pressure and uric acid, according to a systematic review and meta-analysis.
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