Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
2 days ago
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Pearl Toh, 2 days ago
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.

Factors associated with increased mortality in AMD

05 Dec 2017

Survival in age-related macular degeneration (AMD) may be reduced in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2 (AREDS2). Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.

AREDS2 randomized 4,203 patients with at least intermediate AMD to receive lutein/zeaxanthin and/or omega-3 fatty acids for treatment of AMD and cataract. Baseline and annual assessments included best-corrected visual acuity (BCVA), slit-lamp examinations and stereoscopic fundus photographs that were centrally graded for development of late AMD (central geographic atrophy or neovascular AMD) or pseudophakia.

Of the patients, 368 died during a median follow-up of 5 years. In Cox proportional hazards models, mortality was elevated in patients with neovascular AMD in one eye at baseline than in those with no or few drusen (hazard ratio [HR], 1.56; 95 percent CI, 1.21 to 2.01; p<0.001).

Survival was also poor for patients with bilateral cataract surgery before enrolment than for those with baseline bilateral phakia (HR, 1.63; 1.29 to 2.07; p<0.001), as well as for patients with BCVA of <20/40 vs those with ≥20/40 (HR, 1.56; 1.06 to 2.30; p=0.024).

On the other hand, mortality was lower in patients who received antivascular endothelial growth factor therapies for neovascular AMD than in those who did not (HR, 0.71; 0.57 to 0.88; p=0.002).

The association between all-cause mortality and AREDS2 treatment did not significantly differ whether assessing the main or individual treatment effect (omega-3 fatty acids main effect: HR, 1.18; 0.96 to 1.45; p=0.12; lutein/zeaxanthin main effect: HR, 1.04; 0.85 to 1.28; p=0.71).

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Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
2 days ago
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Pearl Toh, 2 days ago
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.