Most Read Articles
Yesterday
In patients with rheumatoid arthritis (RA) who are also positive for anticitrullinated protein antibodies (ACPA), tocilizumab (TCZ) treatment for 2 years increases femoral neck bone mineral density (BMD) and decreases concentrations of bone resorption markers, a recent study has found.
3 days ago
Long-term use of benzodiazepines is independently associated with lower diastolic and systolic blood pressure in ambulatory blood pressure monitoring (ABPM) among older but not younger patients, a study has found.
5 days ago
There appears to be a paradox in the context of smoking and the risk of psoriatic arthritis (PsA), such that current smoking increases the risk of developing PsA in the general population but protects against the same risk among patients with psoriasis, according to a study.
02 Nov 2017
In this issue of MIMS Anti-Infective Supplement, we bring you clinical updates related to combating infectious diseases, and also a symposium highlight in conjunction with the launch of ceftolozane/tazobactam (Zerbaxa; Merck Sharp & Dohme Sdn Bhd) in Malaysia. 

Eyes with cortical opacification show higher Aβ1-43

28 Aug 2017

Japanese patients with cortical opacification have high levels amyloid β1-43 (Aβ1-43) in their lens epithelium, a new study has found.

Normal (controls n=19; mean age 62.8±3.6 years) and opaque (cataract cases n=78; mean age 72.7±1.1 years) lenses were collected from Japanese individuals without diabetes mellitus or Alzheimer’s disease. Levels of Aβ1-40, Aβ1-42, and Aβ1-43 were measured from the samples.

Lens samples were classified according to cataract type: cortical cataract (COR), nuclear cataract (NUC), posterior subcapsular cataract (PSC), retrodots (RD), water clefts (WC), posterior subcapsular opacification, cortical opacification and mixed cataracts with cortical opacification (RD + WC).

There were no significant differences in the levels of Aβ1-40 and Aβ1-42 between controls and patients with WC, RD, PSC, NUC and COR cataracts. On the other hand, Aβ1-43 was not detectable in lenses from controls and PC or WC cataract patients.

Moreover, Aβ1-43 was present only in very low concentrations in the samples from NUC and RD cataract patients. In COR cataracts, Aβ1-43 concentration was 18.5- and 13.9-fold higher than in NUC and WC cataracts, respectively.

The ratio of Aβ1-43 to total Aβ in patients with COR cataract was higher than in NUC, PSD, WC, RD and control participants.

Aβ1-43 levels and Aβ1-43-to-total-Aβ ratio were 26.1- and 13.6-fold higher in mixed cataract patients with cortical opacification than in mixed cataract patients without cortical opacification, respectively.

There were no apparent differences in Aβ1-40, Aβ1-42 and total Aβ concentrations between controls and mixed cataract patients with or without cortical opacification.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Yesterday
In patients with rheumatoid arthritis (RA) who are also positive for anticitrullinated protein antibodies (ACPA), tocilizumab (TCZ) treatment for 2 years increases femoral neck bone mineral density (BMD) and decreases concentrations of bone resorption markers, a recent study has found.
3 days ago
Long-term use of benzodiazepines is independently associated with lower diastolic and systolic blood pressure in ambulatory blood pressure monitoring (ABPM) among older but not younger patients, a study has found.
5 days ago
There appears to be a paradox in the context of smoking and the risk of psoriatic arthritis (PsA), such that current smoking increases the risk of developing PsA in the general population but protects against the same risk among patients with psoriasis, according to a study.
02 Nov 2017
In this issue of MIMS Anti-Infective Supplement, we bring you clinical updates related to combating infectious diseases, and also a symposium highlight in conjunction with the launch of ceftolozane/tazobactam (Zerbaxa; Merck Sharp & Dohme Sdn Bhd) in Malaysia.