Most Read Articles
Rachel Soon, Yesterday

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

Jairia Dela Cruz, 3 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.
5 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
6 days ago
A recent study has shown that the short-term efficacy of tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) for the treatment of acute-on-chronic-liver failure (ACLF) due to reactivation of chronic hepatitis B (CHB).

Extended propranolol use increases treatment success in high-risk infantile hemangioma

30 Aug 2018

Continuing treatment with oral propranolol beyond 6 months and up to 12 months appears to be effective in most patients with high-risk infantile hemangioma (IH), producing meaningful increases in treatment success, a study has shown.

The single-arm, open-label, phase III study included 43 infants aged 35–150 days with high-risk IH, who were initially treated with oral propranolol at 3 mg/kg per day for 6 months (initial treatment period [ITP]). If complete success was not achieved by 6 months, patients were retreated for up to 12 months of age (continuation period). Those who achieved success in the ITP were managed for 3 months without treatment (follow-up period). If rebound growth occurred during the follow-up period, treatment was reinitiated until success for 6 months maximum.

The primary outcome of treatment success after ITP was 47 percent. This number increased to 76 percent up to 12 months of age. Of the patients successfully treated, 68 percent sustained success for 3 months without treatment, with 24 percent requiring retreatment. Treatment success during the retreatment phase was documented in seven of eight patients.

Adverse events, which occurred in 80 percent of patients, were mild and consistent with known propranolol side effects.

The present data show that continuing propranolol treatment for up to 12 months of age effectively increases success rate in high-risk IH, with a satisfactory safety profile, researchers said.

To date, there is no consensus on the optimal duration of treatment with propranolol, which is used in the first-line setting, for IH. However, treatment up to 12 months of age has been proposed for those who do not fully respond to a 6-month course. [Sci Rep 2017;7:43292; J Plast Reconstr Aesthet Surg 2011;64:292-299; J Pediatr Surg 2012;47:707-714]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Rachel Soon, Yesterday

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

Jairia Dela Cruz, 3 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.
5 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
6 days ago
A recent study has shown that the short-term efficacy of tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) for the treatment of acute-on-chronic-liver failure (ACLF) due to reactivation of chronic hepatitis B (CHB).