Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Expression of many miRNAs altered in Alzheimer’s disease

19 Dec 2019
Can Alzheimer’s disease finally be cured?

Several microRNAs (miRNAs) are differentially expressed in the brain, cerebrospinal fluid and blood in Alzheimer’s disease (AD) and may help improve early detection of the disease, reports a recent meta-analysis.

Researchers retrieved 107 publications from the PubMed database, corresponding to 147 independent datasets. Majority of the miRNA expression data were collected from brain tissue (n=60), followed by blood (n=53) and cerebrospinal fluid (n=32) samples. Fifteen datasets reported findings for more than one tissue type.

A total of 260 meta-analyses were carried out on data from brain-derived specimens. Ten percent (n=25) showed study-wide differential expression that achieved statistical significance. Twelve miRNAs were upregulated, while the remaining 13 had their expression levels reduced. Nine miRNAs were classified as having strong evidence due to the consistency of effect across different studies.

Sixty-six meta-analyses were performed on miRNAs extracted from cerebrospinal fluid samples. Of these, five (8 percent) were differentially expressed in AD patients, each with consistent evidence across studies. All five miRNAs were found to be downregulated in patients vs controls.

Blood samples yielded the greatest number of putative miRNA biomarkers. Of the 135 meta-analyses, 24 percent (n=32) showed significantly different expression levels in AD patients; 19 were downregulated, while the rest were enriched. Twenty-one had strong supporting evidence.

Notably, five miRNAs were found to have significantly different expression levels in both brain-derived and blood samples, three of which were upregulated.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.