Most Read Articles
3 days ago
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 3 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
4 days ago
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.

Exposure to cigarette smoke cuts desmopressin efficacy against PMNE in kids

09 May 2020

Cigarette smoke reduces the efficacy of desmopressin as a treatment for children with primary monosymptomatic nocturnal enuresis (PMNE), a recent study has shown.

Researchers retrospectively reviewed the medical records of 81 children (mean age, 9.98±2.62 years; 58.0 percent male) with PMNE who were being treated with 120 mcg sublingual desmopressin. Treatment response was assessed after 3 months. The primary outcome was the impact of cigarette smoke exposure, measured through interviews with the family, on treatment response.

Majority (76.5 percent; n=62) of the participants had severe PMNE symptoms and over half had more than one episode of incontinence per night. The mean number of wet nights a week was 6.24±1.21. More than half were passively exposed to smoke at home.

Notably, while most smoking family members reported engaging in the habit in another room or on the balcony, 25.5 percent said they smoked in the same room as the child. At night, 12.3 percent of the children slept in the same room as the smoker.

After 3 months of treatment, most of the children showed complete response to desmopressin. Exposure to smoke was 40.4 percent in this group, as opposed to 90.9 percent in the subgroup of nonresponders (p=0.002).

Moreover, failure of treatment, characterized as partial and nonresponse, was 55.8 percent in those with smoke exposure, significantly greater than the 26.4-percent failure rate in those without such exposure (p=0.001). Failure was also greater in patients whose parents smoked in the same room (p=0.009).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
3 days ago
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 3 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
4 days ago
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.