Most Read Articles
Saras Ramiya, Yesterday
US researchers show split liver transplantation and living donor liver transplantation (LDLT) may be superior to whole liver transplantation in improving outcomes in paediatric patients.
27 Nov 2017
Chronic hepatitis B virus (HBV) infection is a global problem. Chronic HBV infection is probably the most common maternal infection encountered in Hong Kong, China, and Southeast Asia. In Hong Kong, which is one of the endemic areas, immunisation against HBV was first provided in 1983 to infants born to mothers who were screened positive for hepatitis B surface antigen (HBsAg). Immunisation became widespread since November 1988, but HBsAg-positive mothers are still encountered frequently.1
Yesterday
Dr Michael Lim, consultant of the Division of Paediatric Pulmonary and Sleep in National University Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing paediatric asthma in the primary care setting.
Tristan Manalac, 7 hours ago
There appears to be a link between prenatal ultrasound and autism spectrum disorder (ASD), according to a recent study, which shows an association between greater mean depth of ultrasonographic penetration during the first and second trimesters and ASD relative to typical development.

Exposure to cigarette smoke, air pollution ups risk of juvenile idiopathic arthritis

08 Feb 2018

Exposure to ozone (O3) in the second year of life and cigarette smoke (intrauterine and after birth) and maternal occupational exposure may increase the risk of juvenile idiopathic arthritis (JIA), suggests a recent study.

Intrauterine cigarette smoke exposure (odds ratio [OR], 3.43; 95 percent CI, 1.45‒8.12; p=0.005) and maternal occupational exposure (OR, 13.69; 4.4‒42.3; p<0.001) during pregnancy significantly independently predicted JIA. On the other hand, maternal employment (OR, 0.06; 0.02‒0.2; p<0.001) and ideal maternal weight gain (OR, 0.36; 0.2‒0.8; p=0.017) showed negative associations.

Furthermore, secondhand smoke exposure from birth to JIA diagnosis (OR, 3.6; 1.8‒7.3; p<0.001) and O3 exposure during the second year of life (OR, 2.76; 1.20‒6.37; p=0.017) were significant independent risk factors for the development of JIA.

A total of 66 patients with JIA and 124 age- and sex-matched healthy controls, living in Sao Paulo, Brazil, metropolitan area until JIA diagnosis, and whose mothers resided in this region during pregnancy were included in this exploratory case-control study.

The authors used a structured and reliable questionnaire (κ index for test-retest was 0.80) to analyse demographic data, gestational and perinatal-related factors, and exposure to inhalable environmental elements during pregnancy and after birth (occupational exposure to inhalable particles or volatile vapour, cigarette smoke exposure, and presence of industrial activities or gas stations near the home, work, daycare or school).

Tropospheric pollutants included particulate matter, sulphur dioxide, nitrogen dioxide, O3 and carbon monoxide.

The finding of an association between JIA and exposure to cigarette smoke and air pollution warrants further study, according to the authors.

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Most Read Articles
Saras Ramiya, Yesterday
US researchers show split liver transplantation and living donor liver transplantation (LDLT) may be superior to whole liver transplantation in improving outcomes in paediatric patients.
27 Nov 2017
Chronic hepatitis B virus (HBV) infection is a global problem. Chronic HBV infection is probably the most common maternal infection encountered in Hong Kong, China, and Southeast Asia. In Hong Kong, which is one of the endemic areas, immunisation against HBV was first provided in 1983 to infants born to mothers who were screened positive for hepatitis B surface antigen (HBsAg). Immunisation became widespread since November 1988, but HBsAg-positive mothers are still encountered frequently.1
Yesterday
Dr Michael Lim, consultant of the Division of Paediatric Pulmonary and Sleep in National University Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing paediatric asthma in the primary care setting.
Tristan Manalac, 7 hours ago
There appears to be a link between prenatal ultrasound and autism spectrum disorder (ASD), according to a recent study, which shows an association between greater mean depth of ultrasonographic penetration during the first and second trimesters and ASD relative to typical development.