Exploring the potential of targeted therapy for haematological malignancies

13 Feb 2020
The development of imatinib, a tyrosine kinase inhibitor (TKI), has revolutionised the treatment landscape of chronic myeloid leukaemia (CML); the 10-year survival rate of patients who received imatinib was 83.3%.1,2 Current ELN guidelines recommend either imatinib, nilotinib or dasatinib as first-line treatment for patients with CML.3 Owing to the development of resistance, lack of response or intolerance to imatinib, a proportion of patients initially treated with imatinib will require an alternative therapy.4,5 Moreover, while achieving an early molecular response (EMR; ie, BCR-ABL1IS ≤10% at 3 months) with TKI has been associated with a higher probability of achieving deep molecular response (DMR), the rate of EMR failure is higher with imatinib than nilotinib – a second-generation TKI.6,7
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