Most Read Articles
Jairia Dela Cruz, 3 days ago
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Pearl Toh, 31 Dec 2019
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23 Dec 2019
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Exercise effective for executive function in the long-term

10 Dec 2019
Does it help to be recommending things generally good for the body, as a preventative measure against disease – even if the evidence is inconclusive?

Exercise appears to bear substantial long-term executive functioning benefits in elderly adults with cognitive impairments but not dementia who have cardiovascular disease risk factors, according to a follow-up to the ENLIGHTEN* trial.

ENLIGHTEN randomly assigned 160 volunteers to one of four groups according to a two-by-two factorial design: aerobic exercise (AE) alone (mean age, 65.8±7.3 years; 32 percent male), the DASH** diet alone (mean age, 66.0±7.1 years; 37 percent male), AE with the DASH diet (mean age, 64.9±6.2 years; 35 percent male) or health education (mean age, 64.7±6.6 years; 32 percent male). Neurocognition was measured after 1 year of follow-up using a battery of tests.

Follow-up information was available for 93 percent (n=149) of the participants. Executive function remained significantly better in both exercise groups (p=0.041). Both groups that received the DASH dietary plan intervention also had better executive function, though the difference was only of borderline significance (p=0.054).

To assess the clinical impact of exercise, researchers expressed the improvements in executive function as changes in predicted age. At the 6-month follow-up, those who received both the AE and DASH interventions were better by 8.8 years than baseline, while participants who were randomized to either of the interventions alone had improved by 6.5 years.

The observed trend continued until the 1-year follow-up, such that patients in the group that received both exercise and dietary interventions exhibited improvements of 7.9 years.

*ENLIGHTEN - Exercise and Nutritional Interventions for Neurocognitive Health Enhancement

**DASH - Dietary Approaches to Stop Hypertension

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Most Read Articles
Jairia Dela Cruz, 3 days ago
Metabolic and bariatric surgery (MBS) leads to large and sustained reductions in, and even reversal of, multiple risk factors for future joint disease in adolescents with severe obesity and musculoskeletal pain, according to data from the Teen Longitudinal Assessment of Bariatric Surgery study.
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 6 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.