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Excessive daytime sleepiness predicts Aβ deposition

13 Sep 2018
The latest HLI survey had Hong Kong ranking last among 15 economies where "health satisfaction" was concerned.

Excessive daytime sleepiness (EDS) appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.

Using self-reports, researchers determined EDS and napping patterns in 124 community-dwelling adults (mean age 60.1±9.8 years; 50 percent female). Almost a third (29 percent) of the participants were nappers while 24 percent had EDS. There was no significant correlation between EDS and napping (p=0.24).

Pittsburgh compound B positron emission tomography scans were performed after a mean follow-up duration of 15.7±3.4 years to assess Aβ deposition. At the time of imaging, 4.8 percent (n=6) had been diagnosed with mild cognitive impairment and 34.7 percent (n=43) were positive for Aβ deposits.

Participants with self-reported EDS were significantly more likely to test positive for Aβ deposits at follow-up (56.7 percent vs 28.0 percent; p=0.004).

After adjustments for covariates, multivariable logistic regression analysis showed that the risk of Aβ deposition was 2.75 times higher in those with EDS than in those without (odds ratio [OR], 2.75; 95 percent CI, 1.09–6.95; p=0.033).

A similar trend was observed for nappers. In unadjusted analysis, those with self-reported napping were twice as likely to test positive for Aβ deposits on follow-up than non-nappers, though significance was not reached (OR, 2.01; 0.91–4.50; p=0.091). This relationship was attenuated upon controlling for covariates (OR, 1.86; 0.73–4.75; p=0.194).

The findings indicate that EDS may be a low-cost, simple and noninvasive method with which patients can be risk-stratified according to likelihood of Aβ deposition, said researchers.

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Most Read Articles
4 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
Yesterday
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
6 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
5 days ago
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.