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Excessive daytime sleepiness predicts Aβ deposition

13 Sep 2018
The latest HLI survey had Hong Kong ranking last among 15 economies where "health satisfaction" was concerned.

Excessive daytime sleepiness (EDS) appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.

Using self-reports, researchers determined EDS and napping patterns in 124 community-dwelling adults (mean age 60.1±9.8 years; 50 percent female). Almost a third (29 percent) of the participants were nappers while 24 percent had EDS. There was no significant correlation between EDS and napping (p=0.24).

Pittsburgh compound B positron emission tomography scans were performed after a mean follow-up duration of 15.7±3.4 years to assess Aβ deposition. At the time of imaging, 4.8 percent (n=6) had been diagnosed with mild cognitive impairment and 34.7 percent (n=43) were positive for Aβ deposits.

Participants with self-reported EDS were significantly more likely to test positive for Aβ deposits at follow-up (56.7 percent vs 28.0 percent; p=0.004).

After adjustments for covariates, multivariable logistic regression analysis showed that the risk of Aβ deposition was 2.75 times higher in those with EDS than in those without (odds ratio [OR], 2.75; 95 percent CI, 1.09–6.95; p=0.033).

A similar trend was observed for nappers. In unadjusted analysis, those with self-reported napping were twice as likely to test positive for Aβ deposits on follow-up than non-nappers, though significance was not reached (OR, 2.01; 0.91–4.50; p=0.091). This relationship was attenuated upon controlling for covariates (OR, 1.86; 0.73–4.75; p=0.194).

The findings indicate that EDS may be a low-cost, simple and noninvasive method with which patients can be risk-stratified according to likelihood of Aβ deposition, said researchers.

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Most Read Articles
12 Jun 2019
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
Yesterday
The aromatase inhibitor anastrozole shows promise in the treatment of children with congenital adrenal hyperplasia, reducing bone age advancement without adversely affecting bone mineral density and visceral adipose tissue, as shown in a recent study.
Roshini Claire Anthony, 6 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

6 days ago
The use of opioids may have limited long-term efficacy in the management of chronic noncancer pain, reports a new study.