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Excessive daytime sleepiness predicts Aβ deposition

13 Sep 2018
The latest HLI survey had Hong Kong ranking last among 15 economies where "health satisfaction" was concerned.

Excessive daytime sleepiness (EDS) appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.

Using self-reports, researchers determined EDS and napping patterns in 124 community-dwelling adults (mean age 60.1±9.8 years; 50 percent female). Almost a third (29 percent) of the participants were nappers while 24 percent had EDS. There was no significant correlation between EDS and napping (p=0.24).

Pittsburgh compound B positron emission tomography scans were performed after a mean follow-up duration of 15.7±3.4 years to assess Aβ deposition. At the time of imaging, 4.8 percent (n=6) had been diagnosed with mild cognitive impairment and 34.7 percent (n=43) were positive for Aβ deposits.

Participants with self-reported EDS were significantly more likely to test positive for Aβ deposits at follow-up (56.7 percent vs 28.0 percent; p=0.004).

After adjustments for covariates, multivariable logistic regression analysis showed that the risk of Aβ deposition was 2.75 times higher in those with EDS than in those without (odds ratio [OR], 2.75; 95 percent CI, 1.09–6.95; p=0.033).

A similar trend was observed for nappers. In unadjusted analysis, those with self-reported napping were twice as likely to test positive for Aβ deposits on follow-up than non-nappers, though significance was not reached (OR, 2.01; 0.91–4.50; p=0.091). This relationship was attenuated upon controlling for covariates (OR, 1.86; 0.73–4.75; p=0.194).

The findings indicate that EDS may be a low-cost, simple and noninvasive method with which patients can be risk-stratified according to likelihood of Aβ deposition, said researchers.

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Most Read Articles
6 days ago
Electroretinogram-assessed localized retinal dysfunction in type 1 diabetes mellitus patients appears to occur even in the absence of clinical signs of diabetic retinopathy (DR), and this incidence is associated with ageing, according to a study.
Roshini Claire Anthony, 18 hours ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 3 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
6 days ago
Greater home blood pressure (BP) variability, particularly in home systolic (S)BP, correlates with higher carotid, aortic and peripheral but not coronary atherosclerosis burdens independent of the mean home BP, suggests a recent study.