Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.

Excessive cortisol level contributes to endometrial insulin resistance in PCOS

08 Aug 2018

Polycystic ovary syndrome (PCOS) patients with insulin resistance (IR) have decreased oxidation of cortisol and defects of insulin signaling in the endometrium, a recent study has shown.

In addition, local cortisol elevation, derived from the reduction of 11β-hydroxysteroid dehydrogenases (11β-HSDs) 2, may influence the development of endometrial IR through the inhibition of the insulin signaling pathway via induction of phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression in endometrial epithelial cells (EECs), according to the authors.

There was an elevated cortisol concentration and a diminished 11β-HSD2 expression in endometrial biopsies obtained from PCOS patients with IR compared with those from non-PCOS and PCOS patients without IR.

PCOS patients with IR had a relatively impaired implantation rate and a defective endometrial insulin signaling pathway. Cortisol also lessened insulin-stimulated glucose uptake in EECs, which was mediated by inhibition of Akt phosphorylation and glucose transporter type 4 translocation via induction of PTEN.

The authors sought to determine whether the abundance of 11β-HSD1 and 11β-HSD2 and cortisol, as well as the insulin signaling pathway, are altered in PCOS endometrium, and to clarify the association between endometrial IR and local cortisol.

Cortisol and cortisone concentrations, 11β-HSD1 and 11β-HSD2, and core insulin signaling molecules in endometrial biopsies collected from non-PCOS and PCOS patients with or without IR on the 7th day after human chorionic gonadotropin injection were measured. The authors analysed the effects of cortisol on glucose uptake and the insulin signaling pathway in primary cultured EECs.

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Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.