Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Elvira Manzano, 3 days ago
An investigational transdermal amphetamine patch worn for 9 hours on the hip appeared effective in paediatric patients with attention deficit-hyperactivity disorder (ADHD) in a phase II, two-part trial.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.

Excess weight tied to more severe psoriatic arthritis in women

29 Apr 2021

In a tightly monitored treatment setting, female patients with psoriatic arthritis (PsA) have greater disease severity than their male peers, as shown in a study. Being overweight is a notable risk factor for higher disease activity in women, but not in men.

The analysis used routine practice data and included 855 PsA patients, who were all tightly monitored and treated. Outcomes such as Psoriatic Arthritis Disease Activity Score (PASDAS), skin/nail disease, Short-Form 12 physical and mental component summary scales (SF12-PCS/MCS), and inflammatory back pain (IBP) were assessed and compared between men and women.

Swollen and tender joints, C-reactive protein (CRP), enthesitis, and function, among others, were all unfavourable in women than in men (all p<0.001). Furthermore, women had much higher PASDAS scores (3.5 vs 2.7; p<0.001).

Multivariate logistic regression analyses showed that women were twice as likely as men to fall short of meeting the treatment target of PASDAS ≤3.2 (odds ratio [OR], 2.03; p<0.001). This was despite the similarity in the current medication they used.

Nail disease, IBP, number of disease-modifying antirheumatic drugs (DMARDs) used (past and current), and body mass index (BMI) factored in the failure to attain treatment target in the overall sample.

Finally, higher BMI was associated with failure to achieve PASDAS low disease activity in women (ORs, 2.41–3.43; p<0.001) but not men.

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Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Elvira Manzano, 3 days ago
An investigational transdermal amphetamine patch worn for 9 hours on the hip appeared effective in paediatric patients with attention deficit-hyperactivity disorder (ADHD) in a phase II, two-part trial.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.