Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Roshini Claire Anthony, 12 Feb 2020

Children with inflammatory bowel disease (IBD) do not appear to have an elevated risk of lymphoma following treatment with anti-tumour necrosis factor (TNF) agents, according to a study presented at the recent Crohn’s and Colitis Congress 2020.

Jairia Dela Cruz, 3 days ago
A diet low in fat and high in fibre seems well tolerated in patients with ulcerative colitis, not contributing to increased inflammation while significantly increasing populations of Faecalibacterium prausnitzii, according to a study presented at the 2020 Crohn's & Colitis Congress.
Pearl Toh, 14 Feb 2020
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).

Evidence insufficient for antacid treatment in preterm infants

01 Aug 2018

There is limited evidence supporting the use of antacid therapy in preterm infants with gastro-oesophageal reflux disease (GERD), according to a study.

Researchers conducted a systematic review of studies evaluating the efficacy and safety of histamine-2 receptor antagonists, proton pump inhibitors and alginates vs placebo in preterm infants (<37 weeks gestation) with GERD. They identified a total of six studies involving 302 patients.

A meta-analysis could not be performed owing to a lack of studies evaluating the same intervention with the same outcomes. Data showed that omeprazole therapy markedly decreased the oesophageal acid exposure percentage time with pH <4 (p<0.01) but did not alter GERD symptoms. Sodium alginate significantly reduced gastro-oesophageal reflux episodes (p=0.024).

Meanwhile, the combination of metoclopramide and ranitidine appeared counterintuitive, producing a significant increase in GERD symptoms and resulting in more bradycardia episodes compared with placebo.

No significant results were found for treatment with esomeprazole or lansoprazole vs placebo.

The studies included were heterogeneous with respect to design, study characteristics such as age of participants, and interventions considered for the treatment of GERD. Moreover, sample sizes were small. These factors limit the conclusions that can be drawn from the present review, as well as highlight the gaps in the evidence, researchers said.

As more studies are required to further examine the use of antacids in preterm infants with GERD, caution should be taken when administering these drugs, they added.

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Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Roshini Claire Anthony, 12 Feb 2020

Children with inflammatory bowel disease (IBD) do not appear to have an elevated risk of lymphoma following treatment with anti-tumour necrosis factor (TNF) agents, according to a study presented at the recent Crohn’s and Colitis Congress 2020.

Jairia Dela Cruz, 3 days ago
A diet low in fat and high in fibre seems well tolerated in patients with ulcerative colitis, not contributing to increased inflammation while significantly increasing populations of Faecalibacterium prausnitzii, according to a study presented at the 2020 Crohn's & Colitis Congress.
Pearl Toh, 14 Feb 2020
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).