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Even light alcohol drinking can derail glucose control in men

27 Sep 2020

Even at low levels, alcohol consumption may contribute to glucose intolerance and an impaired insulin secretion in lean or non-obese men, reports a new Japan study.

Researchers conducted a cross-sectional analysis on 402 non-diabetic men aged ≥40 years. Blood samples were collected for the measurement of fasting plasma glucose (FPG), insulin, triglycerides, and cholesterols, while the homeostasis model assessment was used to assess insulin secretion capacity (HOMA-B). A self-administered diet history questionnaire was used to determine alcohol consumption.

Most of the participants were of normal body mass index (BMI; <25 kg/m2; n=277). In this subgroup, 22.7 percent were non-drinkers, 39.4 percent were light-to-moderate drinkers, and 37.9 percent were intensive drinkers.

FPG and HOMA-B values were slightly but significantly worse in light-to-moderate drinkers than in non-drinkers among non-obese participants. This remained true even after controlling for potential confounders, such as age, BMI, medications, regular exercise, current smoking, and a family history of diabetes (FPG: 5.20±0.05 vs 4.92±0.07 mmol/L; p<0.01; HOMA-B: 4.86±4.2 vs 66.0±4.0; p<0.05).

Notably, among participants who had BMI ≥25 kg/m2 (n=125), only intensive drinkers showed significantly elevated FPG and HOMA-B levels. In this subgroup, light-to-moderate drinkers had lower glycated haemoglobin (5.73±0.05 percent vs 5.89±0.06 percent; p<0.05) than non-drinkers.

Multivariate logistic regression analysis confirmed that light-to-moderate alcohol consumption was associated with impaired FPG (odds ratio [OR], 2.598, 95 percent confidence interval [CI], 1.019–6.622) and abnormally low HOMA-B (OR, 2.318, 95 percent CI, 1.002–5.332) relative to non-drinkers in the BMI <25 kg/m2 group.

The same was true for intensive alcohol intake (FPG: OR, 2.907, 95 percent CI, 1.138–7.426; HOMA-B: OR, 2.712, 95 percent CI, 1.016–6.397).

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
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Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
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