Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.

EV-NID1 as potential target for HCC detection and treatment

Christina Lau
08 Sep 2020
From left: Dr Judy Yam, Ms Cherlie Yeung, Dr Sze-Keong Tey

Nidogen 1-enriched extracellular vesicles (EV-NID1) have demonstrated potential as a noninvasive biomarker for early detection of hepatocellular carcinoma (HCC) and as a target for HCC treatment.

Using a mouse model of HCC, researchers from the University of Hong Kong (HKU) found that NID1 in metastatic HCC–derived EVs facilitated lung colonization of tumour cells by enhancing angiogenesis and pulmonary endothelial permeability, and by activating fibroblasts to secrete tumour necrosis factor receptor 1 (TNFR1). EV-NID1 also augmented HCC cell growth and motility. [Adv Sci 2020, doi: 10.1002/advs.202002157]

Administration of anti‐TNFR1 antibody effectively diminished lung metastasis induced by the metastatic HCC cellderived EVs in mice.

In HCC patients, serum EV‐NID1 and TNFR1 were found to be positively correlated with tumour stage, indicating their potential as noninvasive biomarkers for early detection of HCC.

“These results also suggest that blockage of the function and signalling pathways of tumour-derived EVs can be applied as a new therapeutic approach for HCC in the future,” concluded investigator Dr Judy Yam of the Department of Pathology, HKU.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.