Most Read Articles
Stephen Padilla, 28 Nov 2018
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Natalia Reoutova, 5 days ago

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Elaine Soliven, 6 days ago
Adding liraglutide to metformin led to a significantly longer duration of glycaemic control in patients with type 2 diabetes (T2D) compared with an oral antidiabetic drug (OAD), according to the LIRA-PRIME* study presented at ADA 2020.

Europe-derived genetic risk score for T1D also applicable to Indians

27 Jun 2020

A type 1 diabetes (T1D) genetic risk score (GRS) that is effective in Europeans may also accurately differentiate Indian patients from controls, a recent study has found.

The study included 262 T1D patients, 345 type 2 diabetes (T2D) patients, and 324 controls. The T1D GRS included nine single nucleotide polymorphisms (SNPs) that had been validated against a European cohort. All included participants were of Indo-European ancestry. The study outcome was the ability of the nine-SNP panel to distinguish Indian diabetics from controls.

Diabetic participants with autoantibody responses saw significantly higher mean GRS values than in those with clinical T1D but were autoantibody negative (0.76±0.09 vs 0.73±0.1; p=0.03). This indicated the possibility of misclassifications when diagnoses were based on clinical manifestations alone.

Focusing on T1D patients who satisfied both clinical criteria and autoantibody tests, GRS continued to be higher than in T2D (0.76±0.09 vs 0.64±0.07; p<0.0001) and control (0.76±0.09 vs 0.65±0.07; p<0.0001) comparators.

Notably, researchers also found that the current cohort had lower GRS results than European T1D patients (p<0.0001), though the nine-SNP GRS panel nevertheless remained a strong tool to discriminate T1D from T2D (area under the receiver operator-characteristic curve [AUROC], 0.84, 95 percent confidence interval [CI], 0.80–0.87) and from controls (AUROC, 0.82, 95 percent CI, 0.78–0.85) in Indians.

The difference in the GRS’s ability to differentiate T1D from T2D was only slightly but significantly weaker in Indians than in Europeans (AUROC, 0.84 vs 0.87, respectively; p<0.0001).

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Most Read Articles
Stephen Padilla, 28 Nov 2018
A low-carbohydrate diet increases energy expenditure during weight loss maintenance, consistent with the carbohydrate-insulin model, a study has shown. This metabolic effect may contribute to the success of obesity treatment, particularly among those with high insulin secretion.
Natalia Reoutova, 5 days ago

A hospital-based observational cohort study finds an association between higher fasting blood glucose (FBG) levels and unfavourable outcomes, including death, among Chinese patients with diabetes mellitus (DM) following acute ischaemic stroke (AIS).

Elaine Soliven, 6 days ago
Adding liraglutide to metformin led to a significantly longer duration of glycaemic control in patients with type 2 diabetes (T2D) compared with an oral antidiabetic drug (OAD), according to the LIRA-PRIME* study presented at ADA 2020.