Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.

Esophagogastric varices associated with poor prognosis in hepatocellular carcinoma

27 Feb 2017

Esophagogastric varices are independent risk factors for poor prognosis and poor liver functional reserves in patients with hepatocellular carcinoma, a new study reports.

The study included 990 hepatocellular carcinoma patients who were treatment-naïve. Those who did not receive esophagogastroduodenoscopy were excluded. The patients were followed up every 3 months for a median of 13.1 months. Radio-immunoassay was performed to measure the serum levels of hepatitis C virus antibody and hepatitis B surface antigen, and overall survival was used as the primary endpoint.

Of the patients, 95.2 percent were screened for esophagogastric varices and the remaining 4.8 percent for bleeding. Esophagogastroduodenoscopy diagnosed esopahgogastric varices in 480 patients; of these, 399 had esophageal varices alone, 12 had gastric varices alone, and 69 had both.

At the end of the follow-up period, 457 patients survived while 533 died. Patients with esophagogastic varices had lower 1-, 3- and 5-year overall survival rates compared with those without esophagogastric varices (49.4 vs 67.7 percent, 34.7 vs 54.9 and 24.9 vs 46.4 percent, respectively; p<0.001).

After stratification according to the Barcelona Clinic Liver Cancer stages, overall survival rates remained lower among patients with esophagogastric varices than among those without esophagogastric varices with the exception of those with stage D disease. The results were similar regardless of whether patients received either curative or non-curative treatment modalities.

The findings thus show that esophagogastric varices are independent risk factors for poorer prognoses in patients with hepatocellular carcinoma.

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Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.