Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.

Escitalopram beneficial against neuroticism

02 Nov 2019

Treatment with the selective serotonin reuptake inhibitor escitalopram may confer beneficial effects on neuroticism, possibly by inducing reduction in anxiety, a recent study has shown.

Researchers reanalysed data from a randomized placebo‐controlled trial that failed to find an effect of escitalopram on neuroticism and state anxiety in a nonclinical sample to examine the drug’s unique effects on two neuroticism factors, trait anxiety and mood instability.

The study population included 80 adults free of psychiatric disorders but who had a first‐degree relative with major depression. These adults were randomized to receive escitalopram 10 mg/day or placebo for 4 weeks.

A greater reduction in the Eysenck Personality Questionnaire (EPQ) trait anxiety was observed in the escitalopram group, whereas EPQ mood instability decreased more in the placebo group, although neither difference was statistically significant.

Of note, participants in the escitalopram vs placebo group showed a greater decline in the Hamilton Anxiety Rating Scale (HAM‐A) scores, but the difference was only borderline statistically significant (p=0.09).

There was a significant interaction between baseline EPQ neuroticism and treatment condition (p=0.004), such that the effect of escitalopram on HAM‐A scores was statistically significant in participants with higher levels of EPQ trait anxiety, even after controlling for baseline HAM‐A scores.

According to the researchers, the present data could be used to guide future research on the effects of antidepressants in nonclinical populations. They underscored the need to replicate the findings in a properly designed study, given the posthoc and exploratory nature of the current analysis.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.