Most Read Articles
16 Aug 2018
Cognitive impairment appears to be a risk factor for poor adherence to antihypertensive medication among elderly adults without dementia, a recent study has shown.
Roshini Claire Anthony, 15 Aug 2018

Changes in cardiometabolic factors such as body mass index (BMI), glucose levels, and blood pressure (BP) may signify dementia risk up to 14 years pre-diagnosis, with management of these risk factors potentially preventing dementia, according to a French population-based study presented at the Alzheimer’s Association International Conference (AAIC 2018).

09 Oct 2018
An association exists between hypoglycaemia and elevated high-sensitivity cardiac troponin T (hsTnT) levels, a recent study shows. However, such association is probably due to more severe diabetes in patients who developed hypoglycaemia, instead of a direct result of hypoglycaemia.
Roshini Claire Anthony, 5 days ago

The risk of hospitalization due to heart failure was almost halved in patients with secondary mitral regurgitation who underwent transcatheter mitral valve repair plus medical therapy compared with those who underwent medical therapy alone, according to findings of the COAPT* trial.

ESC 0/1-h algorithm safe, effective for early detection of myocardial infarction

09 Aug 2018

A recent study has shown the safety and efficacy of the European Society of Cardiology (ESC) 0/1-h algorithm using high-sensitivity cardiac troponin (hs-cTn) in triaging patients with suspected non–ST-segment elevation myocardial infarction (NSTEMI).

Unselected patients in six countries presenting to the emergency department with symptoms suggestive of NSTEMI were prospectively enrolled. Two independent cardiologists adjudicated the final diagnosis. The authors measured hs-cTnT and hs-cTnI blood concentrations at presentation and after 1 hour.

Safety of rule-out, accuracy of rule-in and overall efficacy were respectively quantified by the negative predictive value (NPV) for NSTEMI, the positive predictive value (PPV), and the proportion of patients triaged towards rule-out or rule-in within 1 hour.

A 17-percent prevalence of NSTEMI was recorded. In 4,368 patients with serial hs-cTnT measurements available, there were high rule-out safety (NPV, 99.8 percent; 2,488 of 2,493), rule-in accuracy (PPV, 74.5 percent; 572 of 768) and overall efficacy by assigning three-fourths of patients either to rule-out (57 percent; 2,493–4,368) or rule-in (18 percent; 768–4,368).

Likewise, safety of rule-out (NPV, 99.7 percent; 1,528 of 1,533), accuracy of rule-in (PPV, 62.3 percent; 498 of 800) and overall efficacy were high among 3,500 patients with serial hs-cTnI measurements by assigning more than two-thirds of patients either to rule-out (44 percent; 1,533 of 3,500) or rule-in (23 percent; 800 of 3,500).

Multiple subgroup analyses, including patients presenting early (≤3 hours) after chest pain onset, confirmed excellent safety, according to the authors.

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Most Read Articles
16 Aug 2018
Cognitive impairment appears to be a risk factor for poor adherence to antihypertensive medication among elderly adults without dementia, a recent study has shown.
Roshini Claire Anthony, 15 Aug 2018

Changes in cardiometabolic factors such as body mass index (BMI), glucose levels, and blood pressure (BP) may signify dementia risk up to 14 years pre-diagnosis, with management of these risk factors potentially preventing dementia, according to a French population-based study presented at the Alzheimer’s Association International Conference (AAIC 2018).

09 Oct 2018
An association exists between hypoglycaemia and elevated high-sensitivity cardiac troponin T (hsTnT) levels, a recent study shows. However, such association is probably due to more severe diabetes in patients who developed hypoglycaemia, instead of a direct result of hypoglycaemia.
Roshini Claire Anthony, 5 days ago

The risk of hospitalization due to heart failure was almost halved in patients with secondary mitral regurgitation who underwent transcatheter mitral valve repair plus medical therapy compared with those who underwent medical therapy alone, according to findings of the COAPT* trial.