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Erectile dysfunction a potential marker of venous thromboembolism risk

05 Apr 2019

The risk of venous thromboembolism (VTE) in men appears to be elevated in the presence of erectile dysfunction (ED), a study has reported.

Researchers looked at 27,771 men participating in the Health Professionals Follow-up Study (HPFS) who had no VTE and prostate cancer at baseline. All participants completed biennial mailed questionnaires to report their current erectile function, which was categorized as ED presence (very poor or poor erectile function) or ED absence (fair, good or very good). Self-reported incident VTE included the first occurrence of either pulmonary embolism (PE) or deep vein thrombosis (DVT).

The average age of the cohort was 65 years, and 31 percent of men reported ED presence. A total of 665 VTE events occurred over 256,678 person-years of follow-up.

In multivariable Cox proportional hazards models, ED presence was associated with a 30-percent increase in the risk of developing VTE (adjusted hazard ratio [HR], 1.3; 95 percent CI, 1.1–1.6; erectile function linear ptrend=0.003).

Results were similar in a subgroup analysis limited to men with confirmed PE (n=196; PEs confirmed by medical record review/participant reconfirmation or self-reported among persons with prior cancer; adjusted HR, 1.3; 0.9–1.8).

Analyses were adjusted for traditional cardiovascular risk factors including age, smoking, body mass index, physical activity, caloric intake, race, alcohol consumption, aspirin use, diabetes, hypertension, hypercholesterolemia, myocardial infarction/angina, and cancer.

The present data indicate that ED presence may signal a higher risk of VTE, researchers said. Erectile function requires both intact arterial inflow and venous occlusion, and it has thus been suggested that ED could be a marker of cardiovascular risk.

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Most Read Articles
10 Apr 2019
Leafy green and root vegetables containing large amounts of nitrate confer substantial defence against salt-induced increases in blood pressure, especially in the context of nonrestricted salt intake, a study has shown.
12 May 2019
Regular consumption of chili pepper is associated with reduced risk of total and cardiovascular death regardless of adherence to Mediterranean diet, according to a study from Italy.
17 Jul 2018
Higher total intake of dairy products, especially yogurt, may help reduce the risk of incident hypertension in middle-aged and older adult men and women, suggests a recent study.
19 Oct 2016
A new system called Preoperative Evaluation Clinic (PEC) workflow for cardiothoracic surgery significantly reduced the cancellation rate of elective cases at the National Heart Centre Singapore (NHCS), according to a study presented at the ASEAN Federation of Cardiology Congress (AFCC) 2016 in Yangon, Myanmar.