Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.

Enzyme activity of P450c21 lessened in lean patients with PCOS

05 Nov 2017

The activity level of P450c21, an adrenal-specific enzyme, is reduced in lean patients with polycystic ovary syndrome (PCOS), suggesting a role of adrenal androgen excess in obesity, a recent study has found.

The study included 1,044 women with PCOS, of which 350 were lean, 312 were overweight and 382 were obese. Patients who were pregnant, had other endocrine disorders, had a history of ovarian surgery, and took medications that may have affected adrenal or gonadal function were excluded.

Liquid chromatography-tandem mass spectrometry was used to compare the steroid hormones with 366 healthy controls (n=203 lean; n=32 overweight; n=131 obese).

In terms of hormone concentrations, lean PCOS patients showed significantly higher levels of dehydroepiandrosterone sulphate (DHEAS; p=0.015), progesterone (p<0.0001) and 17-hydroprogesterone (17-OHP; p<0.001), and significantly lower free androgen index (FAI; p<0.001).

Additionally, enzyme activity of P450c16 (p<0.001), P450aro (p<0.001) and 3βHSD2 (p<0.001) were significantly higher in lean compared with obese PCOS patients. In contrast, enzyme activities of P450c17 (p<0.001) and P450c21 (p=0.001) were significantly decreased in obese PCOS patients.

Body mass index was significantly negatively correlated with the enzyme activities of P450c17 (p=0.004), P450aro (p<0.001) and 3βHSD2 (p<0.001), and significantly positively associated with the activity of P450c21 (p<0.001).

The current findings suggest that “that the adrenal androgen excess played different roles in lean and obese PCOS patients, which represented as different enzyme activity in the steroidogenic pathway,” researchers said.

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Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.