Most Read Articles
Natalia Reoutova, 3 days ago

A retrospective analysis of seven clinical trials demonstrated that neratinib-based therapy is safe and effective in Asian patients with metastatic HER2-positive breast cancer.

Christina Lau, 14 Feb 2019
Progress in the treatment of rare cancers has been named Advance of the Year by the American Society of Clinical Oncology (ASCO).
Pearl Toh, 28 Aug 2019
The addition of radium-223 (Ra223) to enzalutamide for the treatment of mCRPC* was associated with increased fracture risk, which was entirely abolished with mandated use of bone-protecting agents (BPAs) such as zoledronic acid and denosumab, according to interim results of the EORTC 1333 (PEACE III) trial.
Audrey Abella, 28 Aug 2019
A pooled analysis of six trials failed to show noninferiority of a 3-month regimen to a 6-month regimen of oxaliplatin-based chemotherapy for patients with high-risk, stage II colorectal cancer (CRC).

Enzalutamide remains effective, safe at 3 years in hormone-naïve prostate cancer

21 Jan 2018

Treatment with enzalutamide has maintained its antitumour activity in patients with hormone-naïve prostate cancer at 3 years, according to a recent study. In addition, overall bone mineral density, global health status and safety results are comparable to those at 2 years.

None of the patients ceased treatment during year 3. Thirty-eight of 42 patients (90.5 percent; 95 percent CI, 77.4‒97.3) with prostate-specific antigen assessments at 3 years maintained a prostate-specific antigen response. Of 26 patients with metastases at baseline, 17 (65.4 percent) had a complete or partial response as the best overall response during 3 years.

There were minimal mean changes from baseline in total body bone mineral density or bone mineral density of the femoral neck, trochanter, spine L1‒L4, or forearm (range, ‒2.7 to ‒0.1 percent) in patients who completed the 3-year visit.

Total body fat had increased a mean of 16.5 percent, total lean body mass had decreased a mean of ‒6.5 percent, and global health status had minimally decreased from baseline at 3 years. The most frequent adverse events were as follows: fatigue, gynaecomastia, hot flush and nipple pain.

In this study, researchers analysed 67 patients with hormone-naïve prostate cancer and noncastrate testosterone (≥230 ng/dl) who received enzalutamide 160 mg/day orally until disease progression or unacceptable toxicity. Prostate-specific antigen response (≥80 percent decline from baseline) was the primary endpoint.

In a phase II study of enzalutamide monotherapy in patients with hormone-naïve prostate cancer, patients had high prostate-specific antigen response rates at 25 weeks, 1 year and 2 years, with minimal effects on total body bone mineral density and favourable safety, according to researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Oncology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Natalia Reoutova, 3 days ago

A retrospective analysis of seven clinical trials demonstrated that neratinib-based therapy is safe and effective in Asian patients with metastatic HER2-positive breast cancer.

Christina Lau, 14 Feb 2019
Progress in the treatment of rare cancers has been named Advance of the Year by the American Society of Clinical Oncology (ASCO).
Pearl Toh, 28 Aug 2019
The addition of radium-223 (Ra223) to enzalutamide for the treatment of mCRPC* was associated with increased fracture risk, which was entirely abolished with mandated use of bone-protecting agents (BPAs) such as zoledronic acid and denosumab, according to interim results of the EORTC 1333 (PEACE III) trial.
Audrey Abella, 28 Aug 2019
A pooled analysis of six trials failed to show noninferiority of a 3-month regimen to a 6-month regimen of oxaliplatin-based chemotherapy for patients with high-risk, stage II colorectal cancer (CRC).