Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

01 Apr 2016
Amiodarone is safe and effective for early junctional ectopic tachycardia prophylaxis in paediatric patients following open heart surgery, based on a study.
Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.

Entecavir slightly better than lamivudine for patients with HBV-related AE, ACLF

08 Jul 2017

Entecavir and lamivudine demonstrate comparable effects on the mortality rate of patients with chronic hepatitis B virus (HBV)-related acute exacerbation with or without acute-on-chronic liver failure (ACLF), reports a study. In patients with ACLF, however, entecavir delivers a more favourable long-term outcome and is associated with greater clinical improvements.

Researchers performed a comprehensive literature search of studies on therapy involving entecavir or lamivudine for chronic HBV-related acute exacerbation with or without ACLF published before December 2015.

Short- (within 4 months) and long-term (beyond 4 months) mortality were the main outcomes. The secondary outcomes were virological and biochemical responses, ACLF recurrence, and safety.

Three prospective and eight retrospective cohort studies met the inclusion criteria, involving a total of 1,491 patients. Overall, short- (risk ratio [RR], 0.99; 95 percent CI, 0.78 to 1.27) and long-term mortality rates (RR, 0.82; 0.45 to 1.52) were similar among all patients who received entecavir or lamivudine.

On the other hand, long-term outcome was more favourable in patients with ACLF who received entecavir vs lamivudine (RR, 0.60; 0.45 to 0.80). In addition, entecavir yielded more efficient virological and biochemical responses than did lamivudine with respect to the HBV DNA undetectable rate (RR, 1.34; 1.09 to 1.63), HBV DNA reduction rate (weighted mean difference, ‒0.41; ‒0.69 to ‒0.13) and serum alanine aminotransferase normalization rate (RR, 1.13; 1.05 to 1.21).

Additional larger, long-term randomized controlled trials are warranted to confirm these findings, according to researchers.

Oral nucleos(t)ide analogues are commonly given in patients with chronic HBV-related acute exacerbation and ACLF, researchers said. This study provided evidence to the safety and efficacy of entecavir and lamivudine to such patients.

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Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

01 Apr 2016
Amiodarone is safe and effective for early junctional ectopic tachycardia prophylaxis in paediatric patients following open heart surgery, based on a study.
Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.