Most Read Articles
5 days ago
Use of statin appears to reduce the risks of osteoporosis, hip fractures and vertebral fracture in patients newly diagnosed with a stroke, suggests a recent study.
07 Oct 2018
Patients using long-acting opioids with immunosuppressive properties are at greater risk of developing serious infections compared with those using the nonimmunosuppressive opioid counterpart, according to a study.
6 days ago
Speech therapy may effectively reduce excessive supragastric belching, according to a study. This treatment is aimed at increasing awareness of air inhalation and injection manoeuvres, as well as performing exercises to enhance abdominal, quiet and fluent breathing (without sudden stops).
5 days ago
Monitoring of adverse events is lower in ambulatory patients on amiodarone than in those on dofetilide, a recent study has found. Improving the monitoring of such agents may help reduce the risk of morbidity in this population.

Entecavir, tenofovir prevent HBV recurrence in liver transplant patients

21 Sep 2018

Monoprophylaxis with entecavir (ETV) or tenofovir (TDF) following a 6-month combination therapy regimen of hepatitis B immunoglobulin (HBIg) and nucleos(t)ide analogues can prevent recurrence of hepatitis B virus (HBV) infection, a recent study has shown.

Researchers followed 77 liver transplant patients, of whom 69 were infected with HBV (group A; median age 53; 80 percent male), while eight were co-infected with HBV and HDV (group B; median age 45 years; 50 percent male). Patients had been receiving HBIg for at least 6 months. After discontinuation, 54 percent were given TDF while 46 percent received ETV.

The median follow-up time after withdrawal from HBIg was 69 and 61 months for groups A and B, respectively. A total of 70 patients showed a progressive drop in serum HB antibodies titres, which reached levels <10 mIU/mL after a median of 4 months. Only seven patients in group A and one in group B had significant antibody levels throughout the study duration.

There were no reported cases of HBV reinfection. Recurrence of HBV antigens were observed in 9 percent (n=6) of group A; no such case was reported for group B.

Overall recurrence was weak, with the median time from discontinuation of HBIg being 18 months. At the time of recurrence, median serum titres for the antibodies and antigens were 0.25 mIU/mL and 0.06 IU/mL, respectively. Only one patient showed significant recurrence titres (35.2 mIU/mL).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Hepatology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
Use of statin appears to reduce the risks of osteoporosis, hip fractures and vertebral fracture in patients newly diagnosed with a stroke, suggests a recent study.
07 Oct 2018
Patients using long-acting opioids with immunosuppressive properties are at greater risk of developing serious infections compared with those using the nonimmunosuppressive opioid counterpart, according to a study.
6 days ago
Speech therapy may effectively reduce excessive supragastric belching, according to a study. This treatment is aimed at increasing awareness of air inhalation and injection manoeuvres, as well as performing exercises to enhance abdominal, quiet and fluent breathing (without sudden stops).
5 days ago
Monitoring of adverse events is lower in ambulatory patients on amiodarone than in those on dofetilide, a recent study has found. Improving the monitoring of such agents may help reduce the risk of morbidity in this population.