Most Read Articles
Jairia Dela Cruz, 13 Oct 2016
Children born to obese mothers are at increased risk of developing autism spectrum disorder (ASD) compared with children born to normal-weight mothers, according to data from a review and meta-analysis.
Yap Te-Lu, Anette Sundfor Jacobsen, 01 Oct 2013

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies

Yap Te-Lu, Anette Sundfor Jacobsen, 01 Dec 2012

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies.

Yap Te-Lu, Anette Sundfor Jacobsen, 01 Apr 2011

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies.

Endothelial dysfunction in sickle cell anaemia tied to acute chest syndrome in children

11 Sep 2017

Paediatric sickle cell anaemia (SCA) patients suffer from impaired endothelial function, a new study has found. Moreover, those with lower flow-mediated vasodilation (FMD) values have acute chest syndrome (ACS).

In a study sample of 40 paediatric SCA patients (mean age 12.3±3 years; 60 percent male), average FMD values were significantly lower than in the healthy controls (n=25; mean age 11.4±3 years; 28 percent male). Eighteen participants were on hydroxyurea treatment upon enrolment.

According to receiver operator characteristics (ROC) curve analysis, an FMD value of below 11.5 percent could distinguish SCA patients from controls with a sensitivity of 70 percent and a specificity of 80 percent. This suggests that endothelial dysfunction is a marker of SCA.

Patients with a history of ACS within the past year had significantly lower FMD values compared to those with no prior history. ROC curve analysis also showed that FMD could distinguish between those with and without prior ACS histories with an accuracy of 71 percent and a specificity of up to 79 percent. FMD also showed a significantly negative correlation with ACS (p=0.03).

The chances of having a prior ACS history were also significantly higher in paediatric SCA patients with FMD values lower than 6.65 percent (odds ratio, 1.45; 95 percent CI, 1.02 to 3.45; p=0.023).

Paediatric participants aged 6 to 18 years with haemoglobinopathy were recruited and subjected to Doppler ultrasonography to evaluate their endothelial function. Exclusion criteria included acute infection, obesity, systemic inflammation or dyslipidaemia. 

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Most Read Articles
Jairia Dela Cruz, 13 Oct 2016
Children born to obese mothers are at increased risk of developing autism spectrum disorder (ASD) compared with children born to normal-weight mothers, according to data from a review and meta-analysis.
Yap Te-Lu, Anette Sundfor Jacobsen, 01 Oct 2013

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies

Yap Te-Lu, Anette Sundfor Jacobsen, 01 Dec 2012

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies.

Yap Te-Lu, Anette Sundfor Jacobsen, 01 Apr 2011

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies.