Most Read Articles
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
07 Aug 2019
Proton pump inhibitor therapy, particularly with pantoprazole, does not reduce upper gastrointestinal bleeding events in patients taking low-dose anticoagulation/aspirin treatment, reports a recent study.
18 Jul 2019
Colonoscopy in patients under propofol sedation may be enhanced with the water exchange (WE) method by significantly improving colon cleanliness and overall adenoma detection rate (ADR), suggests a recent study.

Endoscopic resection with selective CRT effective for oesophageal squamous cell carcinoma

09 Aug 2019

The combination of endoscopic resection (ER) and selective chemoradiotherapy (CRT) is effective for stage T1b N0M0 thoracic oesophageal squamous cell carcinoma (ESCC), a recent study has found.

Researchers prospectively assessed 176 patients (median age, 63 years; 147 males) with T1b N0M0 thoracic ESCC who underwent ER. Based on resection findings, participants received one of three therapy regimens: no additional treatment (group A; n=74), prophylactic CRT at 41.4 Gy delivered to locoregional lymph nodes (group B; n=83) and definitive CRT at 50.4 Gy with a 9-Gy boost to the primary site (group C; n=13).

The 3-year overall survival rate in group B, the study’s primary outcome, was 90.7 percent (90 percent CI, 84.0–94.7). In the overall sample, the corresponding rate was 92.6 percent (88.5–95.2). This indicated that CRT was either comparable to or superior than surgical intervention, said researchers.

Fifteen patients developed metastatic recurrence of the malignancy, including one in group A, 10 in group B and four in group C. Seven patients with recurrent cancer in only the lymph nodes received salvage surgery; two were alive at the final follow-up. The 3-year progression-free survival rate for the overall sample was 89.7 percent.

There were 18 deaths over the entire study period, though none were related to the treatment regimen. Oesophageal cancer was responsible for 11 deaths, including one in group A, seven in group B and three in group C. Other (brain haemorrhage, acute pancreatitis and pneumonia, among others) and unknown causes accounted for the remaining mortalities.

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Most Read Articles
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
07 Aug 2019
Proton pump inhibitor therapy, particularly with pantoprazole, does not reduce upper gastrointestinal bleeding events in patients taking low-dose anticoagulation/aspirin treatment, reports a recent study.
18 Jul 2019
Colonoscopy in patients under propofol sedation may be enhanced with the water exchange (WE) method by significantly improving colon cleanliness and overall adenoma detection rate (ADR), suggests a recent study.