Most Read Articles
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
6 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.

Endocrine, metabolic disorders tied to poor HRQOL, physical activity in childhood cancer survivors

03 Dec 2019

Endocrine and metabolic disorders independently predict low health-related quality of life (HRQOL) and suboptimal physical activity among childhood cancer survivors, suggests a study.

A total of 7,287 survivors (median age at last follow-up survey, 32 years; range, 18–54 years), of whom 4,884 (67 percent) reported at least one endocrine or metabolic disorder. Those with either disorder were more likely to be male, older, have received radiation therapy and have experienced other chronic health conditions.

After controlling for covariates, endocrine or metabolic disorders were associated with poor physical function (risk ratio [RR], 1.25, 95 percent confidence interval [CI], 1.05–1.48), increased bodily pain (RR, 1.27, 95 percent CI, 1.12–1.44), poor general health (RR, 1.49, 95 percent CI, 1.32–1.68) and lower vitality (RR, 1.21, 95 percent CI, 1.09–1.34).

Furthermore, survivors with growth disorders (RR, 0.90, 95 percent CI, 0.83–0.97), osteoporosis (RR, 0.87, 95 percent CI, 0.76–0.99) and overweight/obesity (RR, 0.92, 95 percent CI, 0.88–0.96) were less likely to meet the recommended physical activity.

This retrospective review with longitudinal follow-up was conducted in a cohort of childhood cancer survivors enrolled in the North American Childhood Cancer Survivor Study to determine the independent effects of endocrine and metabolic disorders on HRQOL and physical activity.

The investigators used the Medical Outcomes Short Form-36 to assess HRQOL and dichotomized participation in physical activity as meeting or not meeting recommendations from the Centers for Disease Control and Prevention. The association of each endocrine or metabolic disorder with HRQOL scales and physical activity was evaluated using log binomial regression.

“Childhood cancer survivors experience chronic health conditions that impact HRQOL and participation in optimal physical activity,” the investigators said.

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Most Read Articles
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
6 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.