Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
5 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.

Emphysema affects FVC decline rate in idiopathic pulmonary fibrosis

09 Jan 2019

Emphysema to an extent of ≥10 percent influences both the annual decline rate and the prognostic significance of forced vital capacity (FVC) in idiopathic pulmonary fibrosis (IPF), suggests a study. Such extent may be used to define combined pulmonary fibrosis and emphysema (CPFE).

The extent of emphysema was ≥5 percent, ≥10 percent and ≥15 percent in 53 (25 percent), 23 (11 percent) and 12 (6 percent) patients. Those with emphysema to an extent of ≥5 percent were more likely to be male and ever-smokers. They also had more preserved lung volume and lower rates of FVC decline compared to those with no or trivial emphysema.

The FVC decline rate significantly predicted mortality in patients with no or trivial emphysema (hazard ratio [HR], 0.933; p<0.001) and in those with an extent of emphysema ≥5 percent (HR, 0.906; p<0.001). However, the diffusing capacity of the lung for carbon monoxide was the most significant prognostic factor in patients with emphysema to an extent of ≥10 percent (HR, 0.972; p=0.040) and ≥15 percent (HR, 0.942; p=0.023).

A 10-percent cutoff value for the extent of emphysema made the most significant difference in the annual FVC decline rate in IPF patients.

This study observed and measured the extent of emphysema on high-resolution computed tomography scans and by a texture-based automated quantification system, respectively, in 209 IPF patients. The impact of differences in the extent of emphysema on the annual decline rate and prognostic significance of lung function parameters was analysed.

“CPFE is characterized by preserved lung volume and slower lung function decline. However, it is unclear at what extent emphysema begins to impact respiratory physiology and prognostic characteristics in IPF,” the authors noted.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
5 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.