Most Read Articles
5 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
Roshini Claire Anthony, 4 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.
4 days ago
The use of opioids may have limited long-term efficacy in the management of chronic noncancer pain, reports a new study.

Emphysema affects FVC decline rate in idiopathic pulmonary fibrosis

09 Jan 2019

Emphysema to an extent of ≥10 percent influences both the annual decline rate and the prognostic significance of forced vital capacity (FVC) in idiopathic pulmonary fibrosis (IPF), suggests a study. Such extent may be used to define combined pulmonary fibrosis and emphysema (CPFE).

The extent of emphysema was ≥5 percent, ≥10 percent and ≥15 percent in 53 (25 percent), 23 (11 percent) and 12 (6 percent) patients. Those with emphysema to an extent of ≥5 percent were more likely to be male and ever-smokers. They also had more preserved lung volume and lower rates of FVC decline compared to those with no or trivial emphysema.

The FVC decline rate significantly predicted mortality in patients with no or trivial emphysema (hazard ratio [HR], 0.933; p<0.001) and in those with an extent of emphysema ≥5 percent (HR, 0.906; p<0.001). However, the diffusing capacity of the lung for carbon monoxide was the most significant prognostic factor in patients with emphysema to an extent of ≥10 percent (HR, 0.972; p=0.040) and ≥15 percent (HR, 0.942; p=0.023).

A 10-percent cutoff value for the extent of emphysema made the most significant difference in the annual FVC decline rate in IPF patients.

This study observed and measured the extent of emphysema on high-resolution computed tomography scans and by a texture-based automated quantification system, respectively, in 209 IPF patients. The impact of differences in the extent of emphysema on the annual decline rate and prognostic significance of lung function parameters was analysed.

“CPFE is characterized by preserved lung volume and slower lung function decline. However, it is unclear at what extent emphysema begins to impact respiratory physiology and prognostic characteristics in IPF,” the authors noted.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
Roshini Claire Anthony, 4 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.
4 days ago
The use of opioids may have limited long-term efficacy in the management of chronic noncancer pain, reports a new study.