Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
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2 days ago
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Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.

Emphysema affects FVC decline rate in idiopathic pulmonary fibrosis

09 Jan 2019

Emphysema to an extent of ≥10 percent influences both the annual decline rate and the prognostic significance of forced vital capacity (FVC) in idiopathic pulmonary fibrosis (IPF), suggests a study. Such extent may be used to define combined pulmonary fibrosis and emphysema (CPFE).

The extent of emphysema was ≥5 percent, ≥10 percent and ≥15 percent in 53 (25 percent), 23 (11 percent) and 12 (6 percent) patients. Those with emphysema to an extent of ≥5 percent were more likely to be male and ever-smokers. They also had more preserved lung volume and lower rates of FVC decline compared to those with no or trivial emphysema.

The FVC decline rate significantly predicted mortality in patients with no or trivial emphysema (hazard ratio [HR], 0.933; p<0.001) and in those with an extent of emphysema ≥5 percent (HR, 0.906; p<0.001). However, the diffusing capacity of the lung for carbon monoxide was the most significant prognostic factor in patients with emphysema to an extent of ≥10 percent (HR, 0.972; p=0.040) and ≥15 percent (HR, 0.942; p=0.023).

A 10-percent cutoff value for the extent of emphysema made the most significant difference in the annual FVC decline rate in IPF patients.

This study observed and measured the extent of emphysema on high-resolution computed tomography scans and by a texture-based automated quantification system, respectively, in 209 IPF patients. The impact of differences in the extent of emphysema on the annual decline rate and prognostic significance of lung function parameters was analysed.

“CPFE is characterized by preserved lung volume and slower lung function decline. However, it is unclear at what extent emphysema begins to impact respiratory physiology and prognostic characteristics in IPF,” the authors noted.

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Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
2 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 5 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.