Most Read Articles
05 May 2019
Statins, when taken before cardiac arrest, improve 1-year survival outcomes, a recent study has found.
Tristan Manalac, 22 Nov 2018
Initial treatment with endovascular therapy results in better amputation-free survival in patients with critical limb ischaemia compared with open surgical bypass, according to a study presented at the American Heart Association Scientific Session 2018 (AHA 2018), held in Chicago, Illinois.
09 May 2019
Cognitive impairments and delirium are frequent postoperative occurrences in patients who undergo coronary artery bypass grafting (CABG) surgery, according to a new meta-analysis.
Tristan Manalac, 29 May 2019
Coronary artery disease is prevalent among patients who have undergone coronary angiography, according to a new Philippine study presented at the recently concluded 2019 Congress of the Asian Pacific Society of Cardiology (APSC 2019). However, the obtained rates remain lower than that in other Asian countries.

Empagliflozin protects against CV risk factors in type 2 diabetes

16 May 2019

Empagliflozin treatment in patients with type 2 diabetes mellitus (T2DM) exerts beneficial effects on cardiovascular (CV) risk factors, including blood pressure (BP) and uric acid, according to a systematic review and meta-analysis.

Researchers searched multiple online databases for randomized, double-blind, placebo-controlled trials evaluating the effects of empagliflozin on blood glucose or BP in patients with T2DM. Inclusion criteria were a follow-up of at least 4 weeks, comparable baseline data between empagliflozin and placebo, and accurate description of statistical method.

The meta-analysis included 12 trials involving 5,781 patients who had been randomized to receive empagliflozin 10 or 25 mg or placebo alone or in addition to background therapy with a mean follow-up of 28 weeks. Patients had T2DM with or without comorbid hypertension.

Pooled data showed that empagliflozin at the 10- or 25-mg dose reduced systolic and diastolic BP, uric acid, glycated haemoglobin (HbA1c), fasting plasma glucose, and body weight in T2DM patients (p<0.001 for all). The glucose-lowering drug conferred no benefits for estimated glomerular filtration rate (p>0.05).

Changes in HbA1c, systolic and diastolic BP, body weight, and lipid profile may partially explain the cardiovascular benefits observed with empagliflozin, according to researchers. These are unlikely to be the main mechanism, as significant outcome benefits were still observed despite adjustments for these factors.

Researchers proposed that several direct effects, not directly mediated by sodium glucose cotransporter 2 inhibition, are partly responsible for the demonstrated cardioprotective effects of the drug. Empagliflozin could have additive cardioprotective effects through the activation of nonclassic renin-angiotensin-aldosterone system pathways, which contribute to reduced risk of CV events.

Furthermore, the drug has been associated with increased glucagon response after meals, with glucagon reported to have positive inotropic and chronotropic effects on the myocardium and help facilitate myocardial glucose uptake even at physiological levels. Therefore, glucagon might be very important for the CV system in T2DM, researchers added.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
05 May 2019
Statins, when taken before cardiac arrest, improve 1-year survival outcomes, a recent study has found.
Tristan Manalac, 22 Nov 2018
Initial treatment with endovascular therapy results in better amputation-free survival in patients with critical limb ischaemia compared with open surgical bypass, according to a study presented at the American Heart Association Scientific Session 2018 (AHA 2018), held in Chicago, Illinois.
09 May 2019
Cognitive impairments and delirium are frequent postoperative occurrences in patients who undergo coronary artery bypass grafting (CABG) surgery, according to a new meta-analysis.
Tristan Manalac, 29 May 2019
Coronary artery disease is prevalent among patients who have undergone coronary angiography, according to a new Philippine study presented at the recently concluded 2019 Congress of the Asian Pacific Society of Cardiology (APSC 2019). However, the obtained rates remain lower than that in other Asian countries.