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Roshini Claire Anthony, 5 days ago

Children who are fully vaccinated against the flu, ie, receive the recommended number of influenza vaccine doses, have a lower risk of acquiring influenza compared with those who are partially vaccinated, a US study found.

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Elevated oestradiol levels protective against OAB during ovulation induction

10 Apr 2020

A sharp increase in oestrogen levels confers a protective effect on overactive bladder (OAB) symptoms in women undergoing ovulation induction, a study has found.

Researchers looked at 100 consecutive women (mean age, 36.9 years) who underwent in-vitro fertilization treatments. They used questionnaires on urinary urgency (USIQ), urinary incontinence (MESA) and lower urinary tract symptoms (BFLUTS-SF) to evaluate OAB symptoms before ovulation induction (low oestradiol level) and prior to ovum pickup (peak oestradiol level).

Forty-nine women had OAB symptoms prior to ovulation induction (mean USIQ severity score, 33), whereas 51 women were asymptomatic. In the symptomatic group, 44 women (90 percent) remained symptomatic (mean USIQ severity score, 34), while five became asymptomatic through ovulation induction.

In the asymptomatic group, on the other hand, 24 women (47 percent) developed OAB symptoms, while 27 (53 percent) remained asymptomatic through ovulation induction. Women who remained asymptomatic had significantly higher mean peak oestradiol levels compared with those who had de novo OAB symptoms (2,069 vs 1,372 pg/ml).

Notably, peak oestradiol levels were >1,500 pg/ml in 63 percent of women who remained asymptomatic but were <1,500 pg/ml in 67 percent of those who became symptomatic.

The present data underscore the possibility of a threshold for oestradiol activity in the lower urinary tract, the researchers said. More studies are warranted to evaluate the efficacy of the various oestrogen preparations and the best treatment modality for OAB symptoms.

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Children who are fully vaccinated against the flu, ie, receive the recommended number of influenza vaccine doses, have a lower risk of acquiring influenza compared with those who are partially vaccinated, a US study found.

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Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
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Treatment with levothyroxine appears to have no significant impact on systolic and diastolic heart function in older adults with mild subclinical hypothyroidism as compared with placebo, results of a study have shown.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.