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Elevated non–HDL-C in young adulthood remains high over life course

10 Jul 2019

A study has revealed that most adults who have elevated nonhigh-density lipoprotein cholesterol (non–HDL-C) early in life will continue to have high non–HDL-C for the rest of their lives, which can significantly increase their risk of cardiovascular disease (CVD).

The authors included a total of 2,516 participants (aged 25–40 years) free of CVD and diabetes from the Framingham Offspring study who had their non–HDL-C progression modeled over eight study examinations (mean follow-up, 32.6 years) using group-based methods.

Kaplan-Meier analyses were performed for those with mean non–HDL-C ≥160 mg/dl (high) and <130 mg/dl (low) at the first two examinations to assess CVD risk based on 25–30 years of follow-up. The authors adjusted the levels of non–HDL-C for participants on lipid treatment using nonparametric algorithm.

Lipid levels among participants showed largely stable trajectories over their 30-year life course. Mean non–HDL-C measured in young adulthood were strongly associated with non–HDL-C levels later in life. Thus, individuals could be delegated to either high or low non–HDL-C groups based on two measurements collected between 25–40 years of age.

On subsequent testing at 25 years, majority (80 percent) of individuals with non–HDL-C ≥160 mg/dl at the first two exams remained in the high group, while a greater proportion (88 percent) of those with non–HDL-C <130 mg/dl remained below 160 mg/dl. Additionally, individuals with high non–HDL-C in young adulthood showed a higher CVD risk in the next 25 years as compared with those with low non–HDL-C (22.6 vs 6.4 percent).

“The results demonstrate that early lipid monitoring before 40 years of age would identify a majority of those with a high likelihood for lifetime elevated lipid levels who also have a high long-term risk for CVD,” the authors said. “This information could facilitate informed patient–provider discussion about the potential benefits of preventive lipid-lowering efforts during the early midlife period.”

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Most Read Articles
5 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 2 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
5 days ago
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2 days ago
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