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Elevated non–HDL-C in young adulthood remains high over life course

10 Jul 2019

A study has revealed that most adults who have elevated nonhigh-density lipoprotein cholesterol (non–HDL-C) early in life will continue to have high non–HDL-C for the rest of their lives, which can significantly increase their risk of cardiovascular disease (CVD).

The authors included a total of 2,516 participants (aged 25–40 years) free of CVD and diabetes from the Framingham Offspring study who had their non–HDL-C progression modeled over eight study examinations (mean follow-up, 32.6 years) using group-based methods.

Kaplan-Meier analyses were performed for those with mean non–HDL-C ≥160 mg/dl (high) and <130 mg/dl (low) at the first two examinations to assess CVD risk based on 25–30 years of follow-up. The authors adjusted the levels of non–HDL-C for participants on lipid treatment using nonparametric algorithm.

Lipid levels among participants showed largely stable trajectories over their 30-year life course. Mean non–HDL-C measured in young adulthood were strongly associated with non–HDL-C levels later in life. Thus, individuals could be delegated to either high or low non–HDL-C groups based on two measurements collected between 25–40 years of age.

On subsequent testing at 25 years, majority (80 percent) of individuals with non–HDL-C ≥160 mg/dl at the first two exams remained in the high group, while a greater proportion (88 percent) of those with non–HDL-C <130 mg/dl remained below 160 mg/dl. Additionally, individuals with high non–HDL-C in young adulthood showed a higher CVD risk in the next 25 years as compared with those with low non–HDL-C (22.6 vs 6.4 percent).

“The results demonstrate that early lipid monitoring before 40 years of age would identify a majority of those with a high likelihood for lifetime elevated lipid levels who also have a high long-term risk for CVD,” the authors said. “This information could facilitate informed patient–provider discussion about the potential benefits of preventive lipid-lowering efforts during the early midlife period.”

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Most Read Articles
Pearl Toh, 10 Oct 2019
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
4 days ago
Eating alone may help in weight management as findings of a recent study suggest that eating with friends lead to higher food intake.
Tristan Manalac, 3 days ago
A digital-first approach, iConnect, allows patients to have greater access to services and guidance and enables healthcare providers to deliver much better postdischarge care, according to Lim Cher Wee, chief operating officer of the Ministry of Health, Office for Healthcare Transformation of Singapore, in his presentation at the recently concluded AsiaPac19 Conference & Exhibition of the Healthcare Information and Management Systems Society (HIMSS 2019).
Jairia Dela Cruz, 3 days ago
Toileting behaviours such as convenience and delayed voiding, straining to void, and position preference are strongly associated with overactive bladder (OAB) symptoms in women, according to a study.