Most Read Articles
6 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
6 days ago
Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.

Elevated fasting glucose protective against osteoporosis

30 Nov 2020

Individuals with high fasting glucose levels have a decreased risk of developing osteoporosis, a study suggests.

The analysis was based on a Korean cohort (mean age, 63.9 years; mean body mass index [BMI], 24.1 kg/m2) of 59,936 men and 36,690 women registered in a national health insurance database. They were grouped according to their baseline fasting glucose (quartile 1, <88 mg/dL; quartile 2, 88–96 mg/dL; quartile 3, 97–107 mg/dL; and quartile 4, ≥108 mg/dL) and glycaemic status (normal, impaired fasting glucose, and diabetes mellitus [DM]).

There were 10,643 (11.01 percent) incident cases of osteoporosis recorded over 399,848.2 person-years of follow-up. Individuals who did versus did not develop the systemic skeletal disorder were older (65.6 vs 63.4 years), more likely to be men (67.6 percent vs 17.0 percent) and less likely to be women (32.4 percent vs 83.0 percent), had greater BMI and waist circumference, and had higher blood pressure and cholesterol levels, among others.

In a multivariate Cox proportional hazard model, elevated fasting glucose conveyed a lower risk of osteoporosis. The risk significantly decreased above the fourth quartile of fasting glucose in men (vs quartile 1: hazard ratios [HRs], 0.80 in quartile 4, 0.88 in quartile 3, and 1.04 quartile 2) and above the third quartile in women (vs quartile 1: HRs, 0.82 in quartile 4, 0.91 in quartile 3, and 0.95 quartile 2).

Osteoporosis risk was lower in men and women with impaired fasting glucose (HR, 0.84, 95 percent confidence interval [CI], 0.76–0.94 and HR, 0.93, 95 percent CI, 0.89–0.98, respectively) and DM (HR, 0.77, 95 percent CI, 0.65–0.91 and HR, 0.75, 95 percent CI, 0.69–0.81) than in individuals with normal glucose.

In light of the findings, impaired fasting glucose is believed to contribute to compensatory hyperinsulinaemia, which helps lower the risk of osteoporosis through anabolic effect of insulin.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
6 days ago
Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.