Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 5 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.

Electronic medical records may facilitate early assessment of ADRD risk

05 Jan 2020
The MOH is exploring options in persuading more private sectors to join the NEHR database.

Electronic medical records (EMR) may help in the early identification of the likelihood of Alzheimer’s disease and related dementias (ADRD), a recent study has found.

Accessing the Indiana Network for Patient care, researchers conducted a case-control study on ADRD patients and age-, race- and sex-matched controls. The derivation population included 10,504 patients and 39,510 controls, while the validation sample had 4,500 cases and 16,952 controls. Both structured and unstructured data (such as progress, medication and visit notes) were retrieved.

Three logistic regression models were constructed using different time periods before the index date: >1 but <10 years (1–10-year model), >3 but <10 years (3–10-year model), and >5 but <10 years (5–10-year model).

Using only structured EMR information, researchers found that including data closer to the patients’ index date improved model performance. For instance, in the validation cohort, the area under the receiver operating characteristic (AUROC) curve was better in the 1–10-year than in the 3–10-year and 5–10-year models (0.689 vs 0.649 and 0.633).

Moreover, restricting the analysis to only those with complete data improved model accuracy, while the effect of proximity of data to index date remained (AUROC, 0.716 vs 0.688 and 0.686, respectively).

Including the unstructured EMR data into the regression models further boosted their performance. In patients in the validation cohort with complete information, the 1–10-year model had an AUROC of 0.826, superior to that of the 3–10-year (AUROC, 0.792) and 5–10-year (AUROC, 0.764) models.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 5 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.