Most Read Articles
Stephen Padilla, 06 Aug 2020
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
06 Aug 2020
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors increase the risk for diabetic ketoacidosis (DKA) by almost threefold, with molecule-specific analyses suggesting a class effect, according to a study.
Stephen Padilla, 3 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.

Electronic medical records may facilitate early assessment of ADRD risk

05 Jan 2020
The MOH is exploring options in persuading more private sectors to join the NEHR database.

Electronic medical records (EMR) may help in the early identification of the likelihood of Alzheimer’s disease and related dementias (ADRD), a recent study has found.

Accessing the Indiana Network for Patient care, researchers conducted a case-control study on ADRD patients and age-, race- and sex-matched controls. The derivation population included 10,504 patients and 39,510 controls, while the validation sample had 4,500 cases and 16,952 controls. Both structured and unstructured data (such as progress, medication and visit notes) were retrieved.

Three logistic regression models were constructed using different time periods before the index date: >1 but <10 years (1–10-year model), >3 but <10 years (3–10-year model), and >5 but <10 years (5–10-year model).

Using only structured EMR information, researchers found that including data closer to the patients’ index date improved model performance. For instance, in the validation cohort, the area under the receiver operating characteristic (AUROC) curve was better in the 1–10-year than in the 3–10-year and 5–10-year models (0.689 vs 0.649 and 0.633).

Moreover, restricting the analysis to only those with complete data improved model accuracy, while the effect of proximity of data to index date remained (AUROC, 0.716 vs 0.688 and 0.686, respectively).

Including the unstructured EMR data into the regression models further boosted their performance. In patients in the validation cohort with complete information, the 1–10-year model had an AUROC of 0.826, superior to that of the 3–10-year (AUROC, 0.792) and 5–10-year (AUROC, 0.764) models.

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Most Read Articles
Stephen Padilla, 06 Aug 2020
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
06 Aug 2020
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors increase the risk for diabetic ketoacidosis (DKA) by almost threefold, with molecule-specific analyses suggesting a class effect, according to a study.
Stephen Padilla, 3 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.