Most Read Articles
Pearl Toh, 31 Dec 2019
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Electrical nerve stimulation helps mitigate movement-evoked pain in fibromyalgia

6 days ago

Use of active transcutaneous electrical nerve stimulation (TENS) in fibromyalgia (FM) patients receiving treatment results in a favourable reduction in movement-evoked pain, according to the results of a trial.

The trial randomized female FM patients receiving steady medication to active TENS (n=103), placebo TENS (n=99) or no TENS (n=99). TENS was applied to the lumbar and cervicothoracic regions using a modulated frequency (2–125Hz) at the highest tolerable intensity, with patients instructed to use it at home 2h/day during activity for 4 weeks.

Movement‐evoked pain (primary outcome) and fatigue were rated on an 11‐point scale before and during application of TENS.

After 4 weeks, movement-evoked pain decreased significantly with active TENS vs placebo TENS (mean difference, –1.0, 95 percent confidence interval [CI], –1.8 to –0.2; p=0.008) and no TENS (mean difference, –1.8, 95 percent CI, –2.6 to –1.0; p<0.0001). The same was observed for fatigue (mean difference, –1.4, 95 percent CI, –2.4 to –0.4; p=0.001 and mean difference, –1.9, 95 percent CI, –2.9 to –0.9; p=0.0001, respectively).

Significantly more patients in the active‐TENS group reported improvement in the global impression of change than in the placebo‐TENS and no-TENS groups (70 percent vs 31 percent and 9 percent, respectively; p-both<0.0001).

There were no reports of TENS‐related serious adverse events, with <5 percent of the overall population experiencing minor adverse events with TENS.

Additional investigation is warranted to examine effectiveness in a real world, pragmatic setting to establish clinical importance of the present data, according to researchers.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 5 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.