Most Read Articles
Roshini Claire Anthony, 2 days ago

A subgroup of patients with HBeAg-negative chronic hepatitis B virus (HBV) infection who ceased their long-term nucleotide analogue treatment maintained virological suppression, pointing to a group of patients who may be suitable for treatment cessation, according to a recent study.

Rachel Soon, 4 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

3 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 6 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.

Elderly adults more likely to die from S. aureus bacteraemia

09 Aug 2018
Scientists have found a way to kill MRSA, the superior version of Staphylococcus aureus.

Advanced age, septic shock and liver cirrhosis increase the risk of mortality in adults with Staphylococcus aureus bacteraemia (SAB), a recent study has shown.

The 4-year retrospective observational study included 337 patients with SAB, of whom 35 percent (n=118) were aged >75 years. Clinical outcomes were compared between participants <75 vs 75 years. Multiple logistic regression analysis was performed to determine risk factors correlated with 7-day and 30-day hospital mortality.

Mortality by days 7 (20.3 percent vs 9.2 percent; p=0.004) and 30 (35.7 percent vs 20.7 percent; p=0.003) were significantly higher in the elderly vs younger adults. In the elderly adult group, septic shock was a risk factor for both 7-day (odds ratio [OR], 8.8; 95 percent CI, 2.7–32; p<0.001) and 30-day (OR, 2.7; 0.9–8.1) mortality.

In comparison, cirrhosis (OR, 8.4; 1.3–75.6; p=0.03) increased the likelihood of 7-day mortality, while adequate ab initio significantly reduced said risk (OR, 0.3; 0.1–0.9; p=0.03). Consultations for infectious diseases significantly reduced the risk of 30-day mortality in elderly adults (OR, 0.3; 0.1–0.7; p=0.006).

Notably, infection with methicillin-resistant S. aureus (MRSA) significantly increased the risk of 30-day mortality (OR, 2.4; 1.0–5.7; p=0.04). Such infections were reported in 39.2 percent (n=132) of the study sample and were equally distributed between the two age groups, though the elderly adults received empirical anti-MRSA treatment with significantly less frequency (15.0 percent vs 36.2 percent; p<0.001).

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Most Read Articles
Roshini Claire Anthony, 2 days ago

A subgroup of patients with HBeAg-negative chronic hepatitis B virus (HBV) infection who ceased their long-term nucleotide analogue treatment maintained virological suppression, pointing to a group of patients who may be suitable for treatment cessation, according to a recent study.

Rachel Soon, 4 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

3 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 6 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.