Most Read Articles
22 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 4 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
2 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
Yesterday
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.

Elderly adults more likely to die from S. aureus bacteraemia

09 Aug 2018
Scientists have found a way to kill MRSA, the superior version of Staphylococcus aureus.

Advanced age, septic shock and liver cirrhosis increase the risk of mortality in adults with Staphylococcus aureus bacteraemia (SAB), a recent study has shown.

The 4-year retrospective observational study included 337 patients with SAB, of whom 35 percent (n=118) were aged >75 years. Clinical outcomes were compared between participants <75 vs 75 years. Multiple logistic regression analysis was performed to determine risk factors correlated with 7-day and 30-day hospital mortality.

Mortality by days 7 (20.3 percent vs 9.2 percent; p=0.004) and 30 (35.7 percent vs 20.7 percent; p=0.003) were significantly higher in the elderly vs younger adults. In the elderly adult group, septic shock was a risk factor for both 7-day (odds ratio [OR], 8.8; 95 percent CI, 2.7–32; p<0.001) and 30-day (OR, 2.7; 0.9–8.1) mortality.

In comparison, cirrhosis (OR, 8.4; 1.3–75.6; p=0.03) increased the likelihood of 7-day mortality, while adequate ab initio significantly reduced said risk (OR, 0.3; 0.1–0.9; p=0.03). Consultations for infectious diseases significantly reduced the risk of 30-day mortality in elderly adults (OR, 0.3; 0.1–0.7; p=0.006).

Notably, infection with methicillin-resistant S. aureus (MRSA) significantly increased the risk of 30-day mortality (OR, 2.4; 1.0–5.7; p=0.04). Such infections were reported in 39.2 percent (n=132) of the study sample and were equally distributed between the two age groups, though the elderly adults received empirical anti-MRSA treatment with significantly less frequency (15.0 percent vs 36.2 percent; p<0.001).

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Most Read Articles
22 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 4 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
2 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
Yesterday
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.