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Roshini Claire Anthony, 21 Dec 2019

In acutely ill medical patients, asymptomatic proximal deep-vein thrombosis (ASxDVT), as assessed via compression ultrasonography, is associated with an elevated risk of all-cause mortality, according to a post hoc analysis of the MAGELLAN* trial presented at ASH 2019.

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Eicosapentaenoic acid confers cardioprotection in heart failure

Jairia Dela Cruz
21 Nov 2018

An increased abundance of eicosapentaenoic acid (EPA) is associated with a reduced risk of heart failure (HF), and this protective effect is independent of established risk factors and ejection fraction status, according to a study presented at the American Heart Association (AHA) Scientific Sessions 2018 in Chicago, Illinois, US.

“Given HF is a leading cause of hospitalization and death in the US and globally, and there are currently no effective treatments for HF with preserved ejection fraction (HFpEF), these findings have important clinical implications,” the authors said.

The study included 6,566 adult participants (52 percent female; 38.55 percent Caucasian) from the Multi-Ethnic Study of Atherosclerosis study who had available baseline EPA data. HF occurred in 293 individuals over a median follow-up of 13.0 years, among whom 129 had HF with reduced ejection fraction, 110 had HFpEF and the remaining 54 had unknown ejection fraction status. [AHA 2018, abstract 026]

Compared with HF-free controls, participants who developed HF had significantly lower mean plasma phospholipid EPA levels (0.70 percent vs 0.77 percent; p=0.002).

Cox proportional hazards analysis revealed that increased EPA levels were associated with a lower incidence of HF (hazard ratio [HR] per unit change in percentage of total fatty acids, 0.73; 95 percent CI, 0.60–0.89; p=0.001).

The association persisted despite adjusting for age, sex, race, body mass index, smoking, diabetes mellitus, blood pressure, lipids and lipid-lowering drugs, and albuminuria. Sensitivity analysis showed no dependence on HF type, and controlling for other fatty acids with clustering did not change the risk estimates.

“We have previously demonstrated in a mouse model of pressure overload-induced HF that EPA preserves contractile function and prevents interstitial myocardial fibrosis,” the authors said.

The present data confirm that EPA is similarly protective in humans, they added.

In animals, EPA level of >2.5 percent is required for prevention of HF, between 2.5 percent and 1 percent is marginal, and <1 percent is insufficient. In the present study, most participants (n=4,794) had insufficient EPA levels, fewer (n=1,471) had marginal levels and fewer still (n=301) had sufficient levels.

“[Individuals] with sufficient EPA levels were at 0.40-fold (0.15–0.81) risk compared to [those with] insufficient EPA (p=0.008),” the authors noted.

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Most Read Articles
Stephen Padilla, 23 May 2019
A recent study has shown an association between regular use of glucosamine supplement to relieve osteoarthritis pain and lower risk of cardiovascular disease (CVD) events.
Stephen Padilla, 6 days ago
The inclusion of two proanthocyanidin (PA)-rich apples into normal diets improves cardiovascular disease (CVD) risk factors by reducing total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and intercellular cell adhesion molecule-1 (ICAM-1), as well as increasing microvascular vasodilation, in individuals with mildly elevated serum cholesterol concentrations, a recent study has shown.
Roshini Claire Anthony, 21 Dec 2019

In acutely ill medical patients, asymptomatic proximal deep-vein thrombosis (ASxDVT), as assessed via compression ultrasonography, is associated with an elevated risk of all-cause mortality, according to a post hoc analysis of the MAGELLAN* trial presented at ASH 2019.

Tristan Manalac, 14 Dec 2019
Luspatercept promotes red blood cell (RBC) transfusion independence among low-risk myelodysplastic syndrome (MDS) patients, according to a longer-term analysis of the MEDALIST study presented at the recently concluded 61st Annual Meeting and Exposition of the American Society of Hematology (ASH 2019).