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ECMO survivors suffer from long-term functional impairments

27 Jun 2019

While patients on extracorporeal membrane oxygenation (ECMO) appear to enjoy good survival rates, long-term quality of life (QoL) and functional deficits still persist, a recent study has found.

The study included 77 ECMO patients (median age, 43 years; 59.7 percent male), in whom the Short Form 36 version 2 (SF36v2) was used to assess health-related QoL.

Majority of the participants (62 percent; n=48) survived to hospital discharge, of whom 42 percent and 58 percent had received venoarterial (VA) and venovenous (VV) ECMO, respectively. Actuarial survival rate at 1 and 3 years was 0.61 (0.41 for VA ECMO and 0.88 for VV ECMO patients). There were no deaths after discharge from the ICU.

After 12 months of follow-up, the mean physical and mental component summary scores in the overall cohort were 46.4±9.9 and 48.7±13.3 years, respectively. Relative to age-matched general population cohorts, ECMO patients showed significantly worse functional outcome scores. Mean score in the Physical Function domain of the SF36v2, for instance, was 65.0±28.5 in survivors, significantly lower than the age-adjusted norms (87.4±6.8; mean difference [MD], –22.4, 95 percent CI, –33.2 to –11.6; p<0.001).

The same was true for the Role Physical (MD, –18.5, –29.4 to –7.6; p=0.002), General Health (MD, –13.8, –22.7 to –4.9; p=0.003), Social Functioning (MD, –11.2, –22.0 to –0.5; p=0.041), Role Emotional (MD, –11.3, –21.8 to –0.8; p=0.036) and Mental Health (MD, –9.0, –18.3 to 0.33; p=0.058) domains.

A return-to-work survey was also administered, revealing that from 61 percent (n=33) of the participants who were employed before ECMO, the proportion of workers dropped to 58 percent (n=19) of the total sample. More than half (52 percent; n=17) were engaged in a form of social or recreational activity.

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Most Read Articles
6 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 4 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
6 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
4 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.