Most Read Articles
2 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.
19 May 2020
A novel telemedicine-based cognitive-behavioural intervention may help manage body image disturbances in survivors of head and neck cancer (HNC), a new study reveals.

Eating behaviour traits partly mediate genetic susceptibility to obesity

27 Sep 2018
One in five children worldwide are either obese or overweight.

It appears that undesirable eating behaviour (EB) traits play a part in mediating genetic susceptibility to obesity, according to a recent study, suggesting that EB traits can be targeted in obesity treatment and prevention.

This cross-sectional study included adult individuals (n=768) who participated in the Quebec Family Study. The authors calculated the genetic risk score (GRS) of obesity based on the 97 genetic variants recently identified in a genome-wide association studies (GWAS) meta-analysis of body mass index (BMI).

The Three-Factor Eating Questionnaire was used to assess EB traits and their subscales. Regression analyses with age and sex as covariates were conducted to examine the associations between GRS, EB traits, BMI and waist circumference (WC), and whether the association between GRS and obesity was mediated by EB traits, representing the indirect effect of GRS on obesity.

A positive association was found between GRS of obesity and BMI (β, 0.19±0.04; p<0.0001) and WC (β, 0.46±0.10; p<0.0001). Regression analyses also showed that disinhibition (βindirect, 0.09±0.03; p=0.0007) and susceptibility to hunger (βindirect, 0.04±0.02; p=0.02) partly mediated the association between GRS of obesity and BMI.

Habitual (βindirect, 0.08±0.03; p=0.002) and situational susceptibility (βindirect, 0.05±0.02; p=0.003) to disinhibition, as well as internal and external locus of hunger (βindirect, 0.03±0.02; p=0.03 for both), also mediated the association between GRS of obesity and BMI. The same trends were seen with WC.

“GWASs have identified several genes associated with obesity. The mechanisms through which these genes affect body weight are not fully characterized. Recent studies suggest that EB traits could be involved, but only a few EB traits were investigated,” the authors said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
2 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.
19 May 2020
A novel telemedicine-based cognitive-behavioural intervention may help manage body image disturbances in survivors of head and neck cancer (HNC), a new study reveals.