Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Early upstream GPI use in acute myocardial infarction patients potentially harmful

08 May 2020

Early upstream use of glycoprotein IIb/IIIa inhibitors (GPIs) in patients with acute myocardial infarction (AMI) should be avoided even in the presence of an intracoronary thrombotic occlusion, as suggested in a study.

The study used data from the Grand Drug-Eluting Stent registry and included 1,329 patients (mean age, 60.4 years; 75.9 percent male) with AMI who had an overt intracoronary thrombus at the initial coronary angiography. Of the patients, 44.7 percent had hypertension, 28.8 percent had diabetes mellitus, and 18.4 percent (n=245) used GPIs.

Compared with nonusers, GPI users had a significantly higher rate of any bleeding events at 30 days (2.9 percent vs 0.9 percent; p=0.015). Multivariable Cox proportional hazards regression analysis confirmed that GPI use was associated with a more than fourfold increase in the risk of 30-day bleeding events (hazard ratio [HR], 4.76, 95 percent confidence interval [CI], 1.66–13.64; p=0.004).

In terms of the efficacy endpoint of a 1-year major adverse cardiovascular event (defined as a composite of all death, myocardial infarction, target lesion revascularization and stent thrombosis), there were no significant differences observed between GPI users and nonusers (9.0 percent vs 7.0 percent, respectively; p=0.287).

Furthermore, GPI use had no significant effect on 1-year major adverse cardiovascular events (HR, 1.33, 95 percent CI, 0.82–2.15; p=0.253).

The present study suggests that even in a population representing patients with a highly thrombotic milieu, GPI use does not reduce adverse clinical outcomes and may even contribute to increased bleeding complications, researchers said. In line with current recommendations, early upstream use of GPIs should not be considered because of the potential harmful effect.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.