Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
4 days ago
The link between sleep duration and hypertension risk appears to be mediated by age and body mass index (BMI), a recent study has found.
04 Nov 2019
Multivessel revascularization (MVR) is better than culprit vessel-only revascularization (CVR) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), reports a recent meta-analysis.
Naomi Rodrig, 04 Sep 2017

Late-breaking data presented at the European Society of Cardiology Congress 2017 in Barcelona, Spain have shown that ibuprofen is associated with greater increase in blood pressure (BP) than celecoxib or naproxen in patients with arthritis, potentially increasing their risk of cardiovascular (CV) events. [Eur Heart J 2017, doi: 10.1093/eurheartj/ehx508]

Early revascularization improves survival in patients with greater ischaemia undergoing PET MPI

01 Oct 2019

Patients with greater ischaemia who underwent positron emission tomography (PET) myocardial perfusion imaging (MPI) have better survival with early revascularization, reports a study. Exploratory analyses reveal a lower threshold than that previously reported for single-photon emission computed tomography (SPECT).

“Prior studies with SPECT MPI have shown a survival benefit with early revascularization in patients with >10–12.5 percent ischemic myocardium,” the authors noted.

This study included a total of 16,029 unique consecutive patients who were undergoing Rubidium-82 rest-stress PET MPI from 2010 to 2016 and excluded those with known cardiomyopathy and nondiagnostic perfusion results. Percent ischaemic myocardium was estimated from a 17-segment model. Nonrandomized referral to early revascularization (90 days of PET) was accounted for using propensity scoring.

Finally, the authors developed a Cox model, adjusting for propensity scores for early revascularization and percent ischaemia, and tested an interaction between ischaemia and early revascularization.

Of the 1,277 (8 percent) patients who underwent early revascularization, 2,491 (15.6 percent) died (738 cardiac) over a median follow-up of 3.7 years. Overall, 5,902 patients (37 percent) had ischaemia, with 2,160 (13.5 percent) having ≥10 percent.

A significant association was observed in propensity-adjusted analyses between ischaemia and early revascularization (p<0.001 for all-cause and cardiac death), such that patients with greater ischaemia had a survival benefit with early revascularization, with a potential ischaemia threshold at 5 percent (upper limit 95 percent CI at 10 percent).

No differential association existed between ischaemia and early revascularization on death based on history of known coronary artery disease (p-interaction=0.72).

“These findings require future validation in prospective cohorts or trials,” the authors said.

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Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
4 days ago
The link between sleep duration and hypertension risk appears to be mediated by age and body mass index (BMI), a recent study has found.
04 Nov 2019
Multivessel revascularization (MVR) is better than culprit vessel-only revascularization (CVR) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), reports a recent meta-analysis.
Naomi Rodrig, 04 Sep 2017

Late-breaking data presented at the European Society of Cardiology Congress 2017 in Barcelona, Spain have shown that ibuprofen is associated with greater increase in blood pressure (BP) than celecoxib or naproxen in patients with arthritis, potentially increasing their risk of cardiovascular (CV) events. [Eur Heart J 2017, doi: 10.1093/eurheartj/ehx508]