Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.

Early RAAS blockade improves short-, long-term renal outcomes in SLE patients with aPLN

23 May 2018
Would your patient really want to know where it came from?

Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

No significant difference was observed in demographic data, laboratory findings and renal histology by the time of kidney biopsy between the RASI and non-RASI groups. However, the former showed higher proteinuria levels than the latter (5.2; 2.8–8.8 vs 1.9; 0.6–2.8 g/day; p=0.005) and higher prevalence of hypertension (75 percent vs 29 percent; p=0.001).

At 12 months after kidney biopsy, there was no significant between-group difference in estimated glomerular filtration rate (eGFR), mean arterial pressure and proteinuria. The RASI group showed significantly higher improvement ratio of eGFR vs the non-RASI group (26 percent; –5 to 86 percent vs –2 percent; –20 to 20; p=0.028). Beyond 12 months, the rate of change in eGFR was similar between the two groups.

Furthermore, kidney disease progression developed in four patients (23 percent) in the non-RASI group and three (8 percent) in the RASI group during a mean follow-up of 80 months. Early RAAS blockade significantly reduced the risk of kidney disease progression (hazard ratio, 0.11; 0.02–0.59; p=0.010).

The two groups had comparable proteinuria and hypertension controls.

To assess the renal protective effects of RAAS with RASI, the investigators analysed medical data of 57 SLE patients with biopsy-proven aPLN. Early RAAS blockade was defined as administration of RASI within 3 months after kidney biopsy and continued for ≥12 months.

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Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.