Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

Tristan Manalac, 2 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Roshini Claire Anthony, 20 Mar 2018

Individuals with type 2 diabetes (T2D) who initiate therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors have lower risks of all-cause death and cardiovascular (CV) outcomes, specifically myocardial infarction (MI) and stroke, compared with those who initiate other glucose-lowering therapies, according to results from the CVD-REAL* 2 study.

Early RAAS blockade improves renal outcomes in SLE patients with aPLN

06 May 2018

Short- and long-term renal outcomes improve with early renin–angiotensin–aldosterone system (RAAS) blockade with renin–angiotensin system inhibitors (RASI) in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study.

“The renal protective effect of RASI was independent of its antihypertensive and antiproteinuric effects,” the investigators said.

Demographic data, laboratory findings and renal histology by the time of kidney biopsy had no significant difference, but the RASI vs the non-RASI group had higher proteinuria levels (5.2; 2.8–8.8 vs 1.9; 0.6–2.8 g/day, respectively; p=0.005) and higher prevalence of hypertension (75 percent vs 29 percent, respectively; p=0.001).

There was no significant between-group difference in estimated glomerular filtration rate (eGFR), mean arterial pressure and proteinuria level at 12 months after kidney biopsy.

The RASI group had significantly higher improvement ratio of eGFR at 12 months compared with the non-RASI group (26 percent; –5 to 86 percent vs –2 percent; –20 to 20 percent, respectively; p=0.028). The rate of change in eGFR beyond 12 months was comparable between the two groups.

Kidney disease progression occurred in four (23 percent) patients in the non-RASI group and three (8 percent) patients in the RASI group during a mean follow-up of 80 months. Early RAAS blockade significantly reduced the risk of kidney disease progression (hazard ratio, 0.11; 0.02–0.59; p=0.010). Additionally, the two groups had similar proteinuria and hypertension controls.

In this study, the investigators analysed medical data of 57 SLE patients with biopsy-proven aPLN. Early RAAS blockade referred to the administration of RASI within 3 months following kidney biopsy and continued for ≥12 months.

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Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

Tristan Manalac, 2 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Roshini Claire Anthony, 20 Mar 2018

Individuals with type 2 diabetes (T2D) who initiate therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors have lower risks of all-cause death and cardiovascular (CV) outcomes, specifically myocardial infarction (MI) and stroke, compared with those who initiate other glucose-lowering therapies, according to results from the CVD-REAL* 2 study.