Most Read Articles
18 Apr 2018
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Early psychosis intervention programmes lead to improved outcomes

14 Mar 2018

In people with first-episode psychosis, early psychosis intervention (EPI) programmes improve outcomes in mortality and other healthcare system indicators, a recent study has shown.

Using linked health administrative data, researchers determined the trends of EPI use in 1,522 individuals with incident, nonaffective psychosis. Cox proportional hazards models were used to compare outcomes, such as involuntary admissions and psychiatric hospitalizations, between those who did and did not use EPI services.

Compared to nonuser controls (n=992), the rate of contact with a primary care physician was significantly lower in those who used EPI services (n=530; hazard ratio [HR], 0.46; 95 percent CI, 0.41–0.52). The median time to first psychiatric contact after the programme was also shorter in those who did vs did not use EPI services (13 vs 73 days).

While rates of hospitalization were significantly higher in those who used EPI services relative to those who did not (HR, 1.42; 1.18–1.71), emergency department use was significantly lower (HR, 0.71; 0.60–0.83). Rates of involuntary admissions were statistically similar between the two groups (HR, 1.04; 0.88–1.22).

All-cause mortality was likewise significantly lower in those who availed of EPI services (HR, 0.24; 0.11–0.53), yielding an absolute risk difference of 2.5 percent. Self-harm behaviour (HR, 0.86; 0.18–4.24) and deaths by suicide (HR, 0.73; 0.29–1.80) were both statistically comparable between the groups.

However, the benefits of EPI did not appear to persist beyond the first 2 years. “[T]here was no significant advantage for EPI service users in the period between 2 and 5 years postadmission, when care is typically stepped down to medical management,” noted researchers.

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 6 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
5 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Pearl Toh, 3 days ago
Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.