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Early progressive feeding ups number of full enteral feeding days in extremely preterm infants

04 Apr 2018

Early progressive feeding is feasible and effective in increasing the number of full enteral feeding days in extremely preterm infants, suggests a recent study.

A total of 60 infants (median gestation age, 26 weeks; mean birth weight, 832 g) were included. The number of full enteral feeding days in the first month after birth differed between groups (median difference favouring the early feeding group: 2 days; 95 percent CI, 0–3 days; p=0.02). In addition, the use of parenteral nutrition (4 vs 8 days; p≤0.01) and the need for central venous access (9 vs 13 days; p≤0.01) decreased with early progressive feeding.

There was no between-group difference in the outcome of culture-proven sepsis (10 percent vs 27 percent; p=0.18), restricted growth (weight, length and head circumference <10th percentile) at 36-week postmenstrual age (25 percent vs 50 percent; p=0.07) and the composite outcome of necrotizing enterocolitis (NEC) or death (27 percent vs 20 percent; p=0.74).

This single-centre study randomized extremely preterm infants (≤28 weeks of gestation) born between September 2016 and June 2017 to receive either early progressive feeding without trophic feeding (early feeding group) or delayed progressive feeding after a 4-day course of trophic feeding (delayed feeding group). Treatment was allocated on or before feeding day 1.

The primary outcome was the number of full enteral feeding days in the first month after birth, and secondary outcomes included death, NEC, culture-proven sepsis, growth percentiles at 36-week postmenstrual age, use of parenteral nutrition and need for central venous access.

“Due to insufficient evidence, extremely preterm infants rarely receive early progressive feeding (small increments of feeding volumes between 1 and 4 days after birth),” researchers said. “We hypothesized that early progressive feeding increases the number of full enteral feeding days in the first month after birth.”

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Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 5 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 5 days ago
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.